Kuznetsova L V, Storozhevykh T P, Pinelis V G, Sokolova I A, Markov Kh M
Patol Fiziol Eksp Ter. 1989 Jan-Feb(1):32-6.
Cardiac output (CO), arterial pressure (AP), and total peripheral resistance of the vessels were studied in rats on the 1st, 5th, and 20th day after the onset of one-kidney vasorenal hypertension. The CO increased by 72% and the peripheral resistance reduced on the 1st day. In stable increase of AD the CO did not differ from the control level. In extracorporeal perfusion of the hindquarters of hypertensive rats in the indicated periods increased reactivity of the vessels to noradrenaline and resistance at maximal dilatation were revealed. These changes were encountered even before statistically significant increase in AP (5th day) and increased with the gradual development of hypertension.
在一侧肾血管性高血压发作后的第1天、第5天和第20天，对大鼠的心输出量（CO）、动脉压（AP）和血管总外周阻力进行了研究。第1天，心输出量增加了72%，外周阻力降低。在去甲肾上腺素持续稳定增加时，心输出量与对照水平无差异。在上述时间段对高血压大鼠后肢进行体外灌注时，发现血管对去甲肾上腺素的反应性增加，最大扩张时的阻力增加。这些变化甚至在动脉压出现统计学显著升高（第5天）之前就已出现，并随着高血压的逐渐发展而增加。
