Pasquié J L, Jover B, du Cailar G, Mimran A
Service de médecine interne G, CHU, hôpital Lapeyronie, Montpellier.
Arch Mal Coeur Vaiss. 1993 Aug;86(8):1109-12.
In order to assess the role of dietary sodium with or without chloride on the development of 2 kidney, 1 clip renovascular hypertension, 49 male Sprague-Dawley rats were fed 3 different diets for 4 weeks after clipping: ad libitum sodium chloride, sodium citrate or sodium-free diet. Sham operated rats were used as control. The final conscious systolic arterial pressure was similar in all hypertensive groups regardless of diet. No change in cardiac index occurred in clipped animals whereas total peripheral resistance raised to a similar extent. In conclusion, sodium restriction did not prevent hypertension. In addition, the anion linked to sodium had no influence on the level of arterial pressure.
为了评估含或不含氯的膳食钠在二肾一夹肾血管性高血压发展过程中的作用，49只雄性斯普拉格-道利大鼠在夹闭肾动脉后接受3种不同饮食4周：自由摄取氯化钠、柠檬酸钠或无钠饮食。假手术大鼠用作对照。无论饮食如何，所有高血压组的最终清醒收缩期动脉压相似。夹闭肾动脉的动物心脏指数无变化，而总外周阻力升高程度相似。总之，限钠并不能预防高血压。此外，与钠相关的阴离子对动脉压水平没有影响。
