Center for Primary Health Care Research, Lund University, Malmö, Sweden
Center for Primary Health Care Research, Lund University, Malmö, Sweden Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, USA.
Eur Respir J. 2016 Sep;48(3):873-9. doi: 10.1183/13993003.00091-2016. Epub 2016 May 12.
Familial clustering of pleural mesothelioma was reported previously, but none of the reports quantified the familial risk of mesothelioma or the association with other cancers. The contributions of shared environmental or genetic factors to the aggregation of mesothelioma were unknown.We used a number of Swedish registers, including the Swedish Multigeneration Register and the Swedish Cancer Register, to examine the familial risk of mesothelioma in offspring. Standardised incidence ratios (SIRs) were used to calculate the risk. Age standardised incidence rates of mesothelioma were calculated from the Swedish Cancer Registry.The incidence of mesothelioma reached its peak rate in 2000 and decreased thereafter. Risk of mesothelioma was significantly increased when parents or siblings were diagnosed with mesothelioma, with SIRs of 3.88 (95% CI 1.01-10.04) and 12.37 (95% CI 5.89-22.84), respectively. Mesothelioma was associated with kidney (SIR 2.13, 95% CI 1.16-3.59) and bladder cancers (SIR 2.09, 95% CI 1.32-3.14) in siblings. No association was found between spouses.Family history of mesothelioma, including both parental and sibling history, is an important risk factor for mesothelioma. Shared genetic factors may contribute to the observed familial clustering of mesothelioma, but the contribution of shared environmental factors could not be neglected. The association with kidney and bladder cancers calls for further study to explore the underlying mechanisms.
先前已有胸膜间皮瘤家族聚集的报道，但尚无报道对间皮瘤的家族风险或与其他癌症的关联进行量化。共享环境或遗传因素对间皮瘤聚集的影响尚不清楚。我们利用了多项瑞典登记处的数据，包括瑞典多代登记处和瑞典癌症登记处，以研究子女患间皮瘤的家族风险。采用标准化发病比（SIR）来计算风险。从瑞典癌症登记处计算出间皮瘤的年龄标准化发病率。间皮瘤的发病率在 2000 年达到峰值，此后呈下降趋势。当父母或兄弟姐妹被诊断患有间皮瘤时，间皮瘤的风险显著增加，SIR 分别为 3.88（95%CI 1.01-10.04）和 12.37（95%CI 5.89-22.84）。在兄弟姐妹中，间皮瘤与肾脏（SIR 2.13，95%CI 1.16-3.59）和膀胱癌（SIR 2.09，95%CI 1.32-3.14）相关。配偶之间无关联。间皮瘤家族史，包括父母和兄弟姐妹的病史，是间皮瘤的一个重要危险因素。遗传因素可能导致观察到的间皮瘤家族聚集，但不能忽视共享环境因素的作用。与肾脏和膀胱癌的关联需要进一步研究以探索潜在机制。
