Ma Ensen, Ren An, Gao Baoxiang, Yang Minxing, Zhao Qichao, Wang Wu, Li Kefeng
Department of Radiology, China-Japan Friendship Hospital, Beijing, People's Republic of China.
Department of Medicine, School of Medicine, University of California, San Diego, CA, USA.
Onco Targets Ther. 2016 Apr 27;9:2377-84. doi: 10.2147/OTT.S98060. eCollection 2016.
To investigate the effect of position and size of tumor region of interest (ROI) on the estimation of lung cancer vascular parameters using 256-slice computed tomography (CT) perfusion.
After institutional review board approval and written informed consent, 16 men and 11 women with lung cancer were enrolled in this CT perfusion study. Perfusion, blood volume, and peak enhancement were determined for 60 or 120 mm(2) circular ROIs placed at the edge, center, and around (outlining) the visible tumor. Average values were obtained by performing ROI analysis twice by the same observers without any procedural changes.
Perfusion, blood volume, and peak enhancement measurements were substantially higher at the edge than at the center for both 60 and 120 mm(2) ROIs (all P<0.05). Measurements varied substantially depending on the ROI size. Perfusion, blood volume, and peak enhancement for the ROIs outlining tumor were intermediate between those at the tumor edge and center. There were significant correlations between median values and interquartile ranges as follows; perfusion (12.51 [7.91-28.10] mL⋅min(-1)⋅100 mL(-1)), blood volume (29.31 [21.82-37.65] mL⋅100 g(-1)), peak enhancement (12.93 [2.42-22.50]) for the ROIs outlining the tumor, and microvascular density ([19.43±8.78] vessels/0.74 mm(2)), respectively (r values were 0.732, 0.590, and 0.544 respectively, all P<0.05).
Spatial and size selection of ROI significantly affects CT perfusion analysis. ROI outlining of entire tumor provides efficient and reliable measurements for clinical assessment of lung cancer using CT perfusion.
探讨感兴趣区（ROI）的位置和大小对采用256层计算机断层扫描（CT）灌注技术评估肺癌血管参数的影响。
经机构审查委员会批准并获得书面知情同意后，16例男性和11例女性肺癌患者纳入本CT灌注研究。对放置在可见肿瘤边缘、中心及围绕（勾勒）肿瘤的60或120 mm²圆形ROI测定灌注、血容量和峰值强化。由相同观察者在无任何操作变化的情况下对ROI分析进行两次，获取平均值。
对于60和120 mm²的ROI，边缘处的灌注、血容量和峰值强化测量值均显著高于中心处（均P<0.05）。测量值因ROI大小而有很大差异。勾勒肿瘤的ROI的灌注、血容量和峰值强化介于肿瘤边缘和中心处的值之间。中位数与四分位间距之间存在显著相关性，如下所示；勾勒肿瘤的ROI的灌注（12.51 [7.91 - 28.10] mL·min⁻¹·100 mL⁻¹）、血容量（29.31 [21.82 - 37.65] mL·100 g⁻¹）、峰值强化（12.93 [2.42 - 22.50]），以及微血管密度（[19.43±8.78] 个/0.74 mm²），r值分别为0.732、0.590和0.544，均P<0.05。
ROI的空间和大小选择显著影响CT灌注分析。勾勒整个肿瘤的ROI可为采用CT灌注进行肺癌临床评估提供有效且可靠的测量值。
