未来十年的挑战：慢性淋巴细胞白血病中的异基因干细胞移植
Challenges for the next decade: allogeneic stem cell transplantation in chronic lymphocytic leukemia.
作者信息
Corradini P, Farina L
机构信息
Department of Hematology, University of Milano , Milan, Italy.
Division of Hematology, Fondazione IRCCS Istituto Nazionale dei Tumori , Milan, Italy.
出版信息
Leuk Suppl. 2012 Aug;1(Suppl 2):S33-4. doi: 10.1038/leusup.2012.19. Epub 2012 Aug 9.
Abstract
Although hematopoietic stem cell transplantation (allogeneic SCT (allo-SCT)) is the treatment of choice for many aggressive hematological malignancies, the role of allo-SCT in chronic lymphocytic leukemia (CLL) is still a matter of debate and can be considered one of the more important challenges for the next decade. In the era of novel drugs and humanized antibodies, the long-term outcome of patients has improved, and a critical reappraisal of autologous and allo-SCT in CLL treatment is warranted.
摘要
尽管造血干细胞移植（异基因造血干细胞移植（allo-SCT））是许多侵袭性血液系统恶性肿瘤的首选治疗方法，但allo-SCT在慢性淋巴细胞白血病（CLL）中的作用仍存在争议，可被视为未来十年更重要的挑战之一。在新型药物和人源化抗体的时代，患者的长期预后有所改善，因此有必要对CLL治疗中的自体和allo-SCT进行批判性重新评估。
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2
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3
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