[糖尿病患儿血清果糖胺和白蛋白测定的临床意义]

[Clinical significance of the determination of serum fructosamine and albumin in children with diabetes mellitus].

作者信息

Vakhrusheva L L, Kniazev Iu A, Sergeeva N A, Martynova M I, Chesnokova T T

出版信息

Probl Endokrinol (Mosk). 1989 Jan-Feb;35(1):22-5.

Abstract

The paper is devoted to a study of the role of serum glycoprotein fructosamine and serum albumin in the pathogenesis of a severe course of insulin dependent diabetes mellitus (IDDM) in children. Fructosamine was determined in 43 pediatric patients with IDDM by direct spectrophotometry using Hoffman-La-Roche kits; albumin, C-peptide and malonic aldehyde were also determined. Disorder of the mechanism of regulation of homeostasis by albumin was shown to play an important role in the pathogenesis of a severe course of IDDM in children. It could be caused by its enhanced glycosylation and a decrease in liver synthesis in some cases as a result of considerable reduction of insulin secretion. A prognostically unfavorable sign was a raised ratio of fructosamine to albumin and enhanced lipid peroxidation against a background of low insulin secretion. The determination of serum levels of fructosamine and albumin can be a valuable diagnostic criterion in examination of children with diabetes mellitus.

摘要

本文致力于研究血清糖蛋白果糖胺和血清白蛋白在儿童胰岛素依赖型糖尿病（IDDM）严重病程发病机制中的作用。采用罗氏试剂盒通过直接分光光度法测定了43例IDDM儿科患者的果糖胺；同时还测定了白蛋白、C肽和丙二醛。结果表明，白蛋白对体内稳态调节机制的紊乱在儿童IDDM严重病程的发病机制中起重要作用。这可能是由于其糖基化增强以及在某些情况下由于胰岛素分泌大幅减少导致肝脏合成减少所致。果糖胺与白蛋白比值升高以及在胰岛素分泌较低的背景下脂质过氧化增强是预后不良的迹象。测定血清果糖胺和白蛋白水平可作为糖尿病患儿检查中有价值的诊断标准。

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