[Role of adrenal and sex steroids in the regulation of pancreatic exocrine function].

The effect of deficiency of adrenal and sex steroids on the microstructure and some chemical compounds ensuring a secretory process in the pancreas was studied in experiments on adult albino rats of both sexes using morphological, histochemical and morphometric methods. Direct correlation of the number of zymogenic granules with steroid-hormonal balance was established. A secretory response of exocrine pancreacytes on steroid insufficiency was ambiguous in animals of different sexes. Bilateral adrenalectomy in male rats led to a complex of morphofunctional changes resulting in disorders of secretion formation and excretion in the pancreas whereas they were unnoticed in female rats. A similar effect was detected in them after combined adrenal- and ovariectomy.