[Effect of adrenergic innervation on the degree of reparation of the thyroid after its resection].

The time course of thyroid functional changes in normal and in partial desympathization was observed in experiments on 250 albino male rats aged 15 days, 1, 3, 6, 12 and 24 mos. Desympathization was induced by the administration of guanethidine at a dose of 15 mg/kg of body mass in the first 14 days after birth. Resection of the two thirds of the gland was performed on the 3rd, 5th, 7th, 15th and 30th days before killing. T3, T4, CT and TSH levels were determined by radioimmunoassay. Analysis of thyroid hormonal patterns showed variability of functional changes of this organ in desympathization. Desympathization at the age of 15 days and one month led to thyroid functional suppression, later on a rise of hormonogenesis was noted as a result of enhanced production of the pituitary body and CT. At the age of 1 and 3 mos. after thyroidectomy the rates of implementation of thyroid reparative potentials in desympathization were much higher than those in controls and were accompanied by a more marked increase in TSH. At the age of 12 mos. the resection of the two thirds of the thyroid caused a progressive decrease in the level of serum TSH which determined a decrease in the rate of normalization of the thyroid status.