Romero R, Wu Y K, Mazor M, Hobbins J C, Mitchell M D
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, Connecticut.
Prostaglandins Leukot Essent Fatty Acids. 1989 Feb;35(2):81-3. doi: 10.1016/0952-3278(89)90169-5.
5-hydroxyeicosatetraenoic acid (5-HETE) is an arachidonate lipoxygenase product capable of stimulating uterine contractility in a dose-dependent manner in vitro. The purpose of this study was to determine if spontaneous human labor at term is associated with changes in the concentration of this metabolite in amniotic fluid. Fluid was retrieved from 36 women not in labor and from 30 women in active labor at term. 5-HETE was determined by radioimmunoassay. The median amniotic fluid concentration of 5-HETE of women in labor was significantly greater than that of women not in labor (3538 pg/ml vs. 1977 pg/ml, respectively; p = 0.05). This observation is consistent with activation of the lipoxygenase pathway of arachidonic acid metabolism during spontaneous human parturition at term.
5-羟基二十碳四烯酸（5-HETE）是一种花生四烯酸脂氧合酶产物，能够在体外以剂量依赖的方式刺激子宫收缩。本研究的目的是确定足月自然分娩的产妇羊水中该代谢物的浓度变化。从36名未临产的妇女和30名足月活跃期分娩的妇女中获取羊水。采用放射免疫分析法测定5-HETE。分娩妇女羊水5-HETE的中位浓度显著高于未分娩妇女（分别为3538 pg/ml和1977 pg/ml；p = 0.05）。这一观察结果与足月自然分娩过程中花生四烯酸代谢的脂氧合酶途径被激活相一致。
