Romero R, Wu Y K, Mazor M, Hobbins J C, Mitchell M D
Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06510.
Am J Obstet Gynecol. 1988 Sep;159(3):655-7. doi: 10.1016/s0002-9378(88)80028-0.
The purpose of this study was to determine whether parturition is associated with changes in the amniotic fluid concentration of leukotriene C4, an arachidonate lipoxygenase metabolite. Amniotic fluid was collected from 36 women not in labor and from 30 women in active labor with cervical dilation of greater than or equal to 6 cm. The concentration of leukotriene C4 was determined by radioimmunoassay. The median amniotic fluid concentration of leukotriene C4 was greater in laboring women than in nonlaboring women: 121 pg/ml (range, 52 to 261 pg/ml) versus 73.5 pg/ml (range, 6 to 249 pg/ml), respectively (p = 0.0008). These data are consistent with activation of the lipoxygenase pathway during spontaneous parturition at term.
本研究的目的是确定分娩是否与白三烯C4（一种花生四烯酸脂氧合酶代谢产物）的羊水浓度变化有关。从36名未临产的妇女和30名宫颈扩张大于或等于6cm的活跃期临产妇女中收集羊水。通过放射免疫测定法测定白三烯C4的浓度。临产妇女羊水白三烯C4的中位浓度高于未临产妇女：分别为121 pg/ml（范围为52至261 pg/ml）和73.5 pg/ml（范围为6至249 pg/ml）（p = 0.0008）。这些数据与足月自然分娩期间脂氧合酶途径的激活一致。
