竹节参纤溶作用的研究。
Studies of Panax japonicus fibrinolysis.
作者信息
Matsuda H, Samukawa K, Fukuda S, Shiomoto H, Tung C N, Kubo M
出版信息
Planta Med. 1989 Feb;55(1):18-21. doi: 10.1055/s-2006-961767.
The effects of a 70% methanol extract (PMe) obtained from the rhizomes of Panax japonicus C. A. Meyer on experimental thrombosis and fibrinolysis were investigated in vivo and in vitro. PMe showed a promotive effect on the activation of the fibrinolytic system as determined by the euglobulin lysis time (ELT) assay but was inactive to the inhibitory effect against endotoxin-induced disseminated intravascular coagulation (DIC) in rats. PMe and its major components, chikusetsusaponin III, IV, and V, strongly promoted the action of urokinase in fibrin plate. These results suggested that PMe promotes the fibrinolysis and its effective components are chikusetsusaponin III, IV, and V.
研究了从人参（Panax japonicus C. A. Meyer）根茎中提取的70%甲醇提取物（PMe）对体内外实验性血栓形成和纤维蛋白溶解的影响。通过优球蛋白溶解时间（ELT）测定发现，PMe对纤维蛋白溶解系统的激活具有促进作用，但对大鼠内毒素诱导的弥散性血管内凝血（DIC）的抑制作用无活性。PMe及其主要成分竹节人参皂苷III、IV和V在纤维蛋白平板中强烈促进尿激酶的作用。这些结果表明，PMe促进纤维蛋白溶解，其有效成分是竹节人参皂苷III、IV和V。
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