Nagai T, Yamada H, Otsuka Y
Planta Med. 1989 Feb;55(1):27-9. doi: 10.1055/s-2006-961769.
Of 266 Chinese crude drugs, the hot water extract from the root of Scutellaria baicalensis showed potent mouse liver sialidase inhibitory activity; in addition, wogonin, wogonin glucuronide, baicalein, and baicalin were identified as the inhibitors. These flavonoids showed almost the same inhibitory activity when 50-125 micrograms/ml doses of the samples were used for the assay, while wogonin and baicalein showed a more potent activity than wogonin glucuronide and baicalin at the lower concentration (10 micrograms/ml). However, these flavonoids, except wogonin, showed negligible inhibitory activity against Arthrobacter ureafaciens sialidase. These results indicated that S. baicalensis extract contains the sialidase inhibitors which are specific to mouse liver sialidase.
在266种中药材中，黄芩根的热水提取物显示出强大的小鼠肝脏唾液酸酶抑制活性；此外，汉黄芩素、汉黄芩苷元、黄芩素和黄芩苷被鉴定为抑制剂。当使用50 - 125微克/毫升剂量的样品进行测定时，这些黄酮类化合物表现出几乎相同的抑制活性，而在较低浓度（10微克/毫升）下，汉黄芩素和黄芩素的活性比汉黄芩苷元和黄芩苷更强。然而，除汉黄芩素外，这些黄酮类化合物对解脲节杆菌唾液酸酶的抑制活性可忽略不计。这些结果表明，黄芩提取物含有对小鼠肝脏唾液酸酶具有特异性的唾液酸酶抑制剂。
