Acar Berrin, Ozay Ali C, Ozay Ozlen E, Okyay Emre, Sisman Ali R, Ozaksoy Dinc
Department of Obstetrics and Gynecology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Department of Obstetrics and Gynecology, School of Medicine, Dokuz Eylul University, Izmir, Turkey.
Int J Gynaecol Obstet. 2016 Jul;134(1):53-7. doi: 10.1016/j.ijgo.2015.11.025. Epub 2016 Apr 13.
To investigate the relationship between thyroid function status and bone mineral density (BMD) among women with postmenopausal osteoporosis.
A retrospective study was performed among 1217 women aged 45-80years who attended the Department of Obstetrics and Gynecology at Dokuz Eylul University, Izmir, Turkey, between August 1, 2009, and June 1, 2013. Eligible participants were grouped according to the presence or absence of osteoporosis as defined by BMD measurements at the lumbar vertebrae (L1-L4), femoral neck, or trochanter of the femur. Serum levels of free tri-iodothyronine, free tetraiodothyronine, and thyroid-stimulating hormone (TSH) were assessed.
The 303 women with osteoporosis had a lower mean TSH level (1.8mIU/L) than did the 914 women without osteoporosis (1.9mIU/L; P=0.01). A positive correlation between TSH level and measures of BMD was observed (P=0.01). The TSH level was associated with a protective effect in a regression model for development of osteoporosis; the odds ratio was 0.68 (95% confidence interval 0.53-0.86).
Osteoporosis appeared to be independently associated with serum TSH level. Maintaining TSH levels within the upper limit of the reference range during treatment of hypothyroidism could be important to prevent osteoporosis among postmenopausal women.
探讨绝经后骨质疏松症女性的甲状腺功能状态与骨密度（BMD）之间的关系。
对2009年8月1日至2013年6月1日期间在土耳其伊兹密尔多库兹艾吕尔大学妇产科就诊的1217名45 - 80岁女性进行回顾性研究。根据腰椎（L1 - L4）、股骨颈或股骨转子处的骨密度测量结果所定义的骨质疏松症的有无，将符合条件的参与者分组。评估血清游离三碘甲状腺原氨酸、游离甲状腺素和促甲状腺激素（TSH）水平。
303名骨质疏松症女性的平均TSH水平（1.8mIU/L）低于914名无骨质疏松症的女性（1.9mIU/L；P = 0.01）。观察到TSH水平与骨密度测量值之间存在正相关（P = 0.01）。在骨质疏松症发生的回归模型中，TSH水平具有保护作用；比值比为0.68（95%置信区间0.53 - 0.86）。
骨质疏松症似乎与血清TSH水平独立相关。在甲状腺功能减退症治疗期间将TSH水平维持在参考范围的上限对于预防绝经后女性骨质疏松症可能很重要。
