Özbek Ayşe Elverdi, Korkmaz Hüseyin, Sözen Mehmet, İpekçi Süleyman Hilmi, Abuşoğlu Sedat, Kıraç Cem Onur, Ünlü Ali, Kebapçılar Levent
Department of İnternal Medicine, Selcuk University, Konya, Turkey.
Department of Gastroenterology, Selçuk University Faculty of Medicine, Konya, Turkey.
Indian J Clin Biochem. 2024 Jan;39(1):130-135. doi: 10.1007/s12291-022-01080-6. Epub 2022 Sep 6.
In this study, it was aimed to assess effects of subclinical hyperthyroidism (SH) on bone metabolism using osteoprotegerin (OPG), sclerostin, Dickkopf-1 (DKK1) and biochemical parameters. This cross-sectional prospective study included 40 patients with SH and 40 euthyroid controls. Serum OPG, sclerostin, DKK-1, type-1 procollagen, C-terminal polypeptide (CTx) and 24-hours urine N-terminal telopeptide (NTx) were measures using ELISA kit. Bone mineral density measurements were performed using dual energy X-ray absorptiometry (DEXA). Risk for 10-years hip and major fracture was estimated by Turkish version of FRAX. No significant difference was detected in age, gender, body mass index, smoking and menopause rates between SH and control groups. The risk for 10-years hip fracture and major osteoporotic fracture were estimated as 4.45% and 0.55% in SH group, respectively. The OPG levels were significantly lower in patients with SH than controls ( = 0.017). No significant difference was detected in other bone formation and degradation parameters. No significant correlation was detected between OPG level and risk for major osteoporotic fracture ( > 0.05); however, a negative correlation was detected between OPG level and risk for hip fracture (rho = 0.233; = 0.038). Serum OPG is markedly affected in patients with SH. In addition, OPG seemed to be associated with osteoporotic fracture risk. Available data show that SH is significantly associated with risk for fracture; thus, it is important to assess risk for fracture in patients with SH.
在本研究中，旨在使用骨保护素（OPG）、硬化蛋白、Dickkopf-1（DKK1）和生化参数评估亚临床甲状腺功能亢进症（SH）对骨代谢的影响。这项横断面前瞻性研究纳入了40例SH患者和40例甲状腺功能正常的对照者。使用酶联免疫吸附测定（ELISA）试剂盒检测血清OPG、硬化蛋白、DKK-1、I型前胶原、C端多肽（CTx）和24小时尿N端肽（NTx）。使用双能X线吸收法（DEXA）进行骨密度测量。采用土耳其语版FRAX评估10年髋部骨折和主要骨折的风险。SH组和对照组在年龄、性别、体重指数、吸烟率和绝经率方面未检测到显著差异。SH组10年髋部骨折和主要骨质疏松性骨折的风险估计分别为4.45%和0.55%。SH患者的OPG水平显著低于对照组（P = 0.017）。在其他骨形成和降解参数方面未检测到显著差异。OPG水平与主要骨质疏松性骨折风险之间未检测到显著相关性（P>0.05）；然而，OPG水平与髋部骨折风险之间检测到负相关性（rho = 0.233；P = 0.038）。SH患者的血清OPG受到显著影响。此外，OPG似乎与骨质疏松性骨折风险相关。现有数据表明，SH与骨折风险显著相关；因此，评估SH患者的骨折风险很重要。
