Nejati Vahid, Zahmatkesh Ensieh, Babaei Mohammad
Department of Histology and Embryology, Faculty of Science, Urmia University, Urmia, Iran.
Department of Veterinary Anatomy and Embryology, Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran.
Iran Biomed J. 2016 Sep;20(4):229-34. doi: 10.7508/ibj.2016.04.007. Epub 2016 May 14.
The present study was carried out to investigate the possible protective effects of royal jelly (RJ) on oxymetholone (OXM)-induced oxidative liver injuries in mice.
In total, 32 adult male NMRI mice were divided into four groups of eight mice each. Mice in groups 1 and 2 were orally administered 5 mg/kg/day OXM for 30 days. At the same time, mice in group 3 received RJ at a dose of 100 mg/kg/day. Saline control and RJ control groups were also included in this study.
Administration of 5 mg/kg OXM resulted in a significant decrease in total antioxidant capacity and catalase activity, as well as a significant increase in malondialdehyde (P<0.05). In addition, OXM-administrated mice showed a slight increase in liver enzymes, including alanine amino transferase, aspartate amino transferase, and alkaline phosphatase. Although OXM caused histopathological changes in the liver, RJ could significantly improve all of the above-mentioned parameters at a dose of 100 mg/kg.
The results of the present study indicated that RJ has a partially protective effect on OXM-induced liver toxicity in mice.
本研究旨在探讨蜂王浆（RJ）对氧甲氢龙（OXM）诱导的小鼠肝脏氧化损伤的潜在保护作用。
总共32只成年雄性NMRI小鼠被分为四组，每组8只。第1组和第2组小鼠口服5mg/kg/天的氧甲氢龙，持续给药30天。同时，第3组小鼠接受100mg/kg/天的蜂王浆。本研究还包括生理盐水对照组和蜂王浆对照组。
给予5mg/kg的氧甲氢龙导致总抗氧化能力和过氧化氢酶活性显著降低，丙二醛含量显著增加（P<0.05）。此外，给予氧甲氢龙的小鼠肝脏酶（包括丙氨酸氨基转移酶、天冬氨酸氨基转移酶和碱性磷酸酶）略有升高。尽管氧甲氢龙引起了肝脏的组织病理学变化，但100mg/kg剂量的蜂王浆能够显著改善上述所有参数。
本研究结果表明，蜂王浆对氧甲氢龙诱导的小鼠肝脏毒性具有部分保护作用。
