在肥胖的中国 2 型糖尿病患者中，血清β-促细胞生成素水平降低与 Roux-en-Y 胃旁路术后空腹血糖改善及胰岛素分泌能力提高相关：一项 1 年随访研究

Decreased serum betatrophin levels correlate with improved fasting plasma glucose and insulin secretion capacity after Roux-en-Y gastric bypass in obese Chinese patients with type 2 diabetes: a 1-year follow-up.

作者信息

Guo Kaifeng, Yu Haoyong, Lu Junxi, Bao Yuqian, Chen Haibing, Jia Weiping

机构信息

Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao tong University Affiliated Sixth People's Hospital, Shanghai, China.

出版信息

Surg Obes Relat Dis. 2016 Aug;12(7):1343-1348. doi: 10.1016/j.soard.2016.01.024. Epub 2016 Jan 29.

DOI:10.1016/j.soard.2016.01.024

PMID:27178609

Abstract

BACKGROUND

There is increasing evidence that serum betatrophin levels, a hormone derived from adipose tissue and liver, are elevated in type 2 diabetes (T2D).

OBJECTIVE

To investigate the relationships among betatrophin and metabolic control, insulin resistance, and pancreatic β-cell function in obese Chinese patients with T2D who underwent Roux-en-Y gastric bypass (RYGB).

SETTING

University hospital, China.

METHODS

This 1-year follow-up study included 34 obese individuals with T2D (18 males, 16 females) who underwent RYGB in our hospital. Anthropometric results, glucose levels, lipid profiles, and serum betatrophin levels were determined before and 1 year after RYGB.

RESULTS

The serum betatrophin level decreased significantly after RYGB (72.0 ng/mL [33.4-180.9] versus 35.7 ng/mL [14.8-103.3]); P<.001]. The change in betatrophin was significantly positively correlated with the changes in hemoglobin A1c and fasting plasma glucose and negatively correlated with the changes in the 2-hour C-peptide/fasting C-peptide and homeostasis model of assessment of β-cell function (P<.05). Multiple stepwise regression analysis indicated that the change in the serum betatrophin level was independently and significantly associated with the changes in fasting plasma glucose (β = .586, P<.001) and 2-hour C-peptide/fasting C-peptide (β = -.309, P = .021).

CONCLUSION

Circulating betatrophin might be involved in the regulation of glucose control and insulin secretion in obese Chinese with T2D soon after RYGB.

摘要

背景

越来越多的证据表明，血清β-促细胞生成素水平在2型糖尿病（T2D）患者中升高，β-促细胞生成素是一种源自脂肪组织和肝脏的激素。

目的

探讨接受Roux-en-Y胃旁路术（RYGB）的肥胖中国T2D患者中，β-促细胞生成素与代谢控制、胰岛素抵抗及胰岛β细胞功能之间的关系。

地点

中国某大学医院。

方法

这项为期1年的随访研究纳入了34例在我院接受RYGB手术的肥胖T2D患者（18例男性，16例女性）。在RYGB手术前及术后1年测定人体测量结果、血糖水平、血脂谱及血清β-促细胞生成素水平。

结果

RYGB术后血清β-促细胞生成素水平显著降低（72.0 ng/mL[33.4 - 180.9]对比35.7 ng/mL[14.8 - 103.3]；P <.001）。β-促细胞生成素的变化与糖化血红蛋白和空腹血糖的变化呈显著正相关，与2小时C肽/空腹C肽及β细胞功能评估的稳态模型的变化呈负相关（P <.05）。多元逐步回归分析表明，血清β-促细胞生成素水平的变化与空腹血糖的变化（β =.586，P <.001）及2小时C肽/空腹C肽的变化（β = -.309，P =.021）独立且显著相关。