Department of Otolaryngology-Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, 600 Yishan Road, Shanghai, 200233, China.
Shanghai Key Laboratory of Sleep Disordered Breathing, Shanghai, 200233, China.
Sci Rep. 2021 Jan 19;11(1):1808. doi: 10.1038/s41598-021-81379-1.
Obesity is strongly correlated with obstructive sleep apnea (OSA), and bariatric surgery can effectively treat obesity and alleviate OSA. However, the contributing factors are still unclear. We aimed to explore the relationship between betatrophin and OSA in patients undergoing Roux-en-Y gastric bypass (RYGB) surgery. Our study consisted of thirty-seven individuals with OSA and type 2 diabetes (16 males, 21 females) undergoing RYGB surgery. The polysomnography test, anthropometric results, serum betatrophin, and abdominal magnetic resonance images were evaluated both before and 1 year after RYGB surgery. Factors that may correlate with the alleviation of OSA were investigated. In our study, RYGB surgery significantly decreased apnea hypopnea index (AHI) and serum betatrophin concentration (p < 0.001). The abdominal visceral fat area, subcutaneous fat area and HOMA-IR were also significantly decreased (p < 0.001). The preoperative AHI, postoperative AHI and the change in AHI were significantly correlated with the preoperative betatrophin, postoperative betatrophin and the change in betatrophin, respectively (p < 0.05). These correlations were still significant after adjustment for other risk factors. The change in betatrophin was also independently associated with the change in minimum oxygen saturation (p < 0.001). Our data might indicate that serum betatrophin was significantly independently correlated with the improvement of OSA after bariatric surgery.
肥胖与阻塞性睡眠呼吸暂停（OSA）密切相关，减重手术可以有效治疗肥胖症并缓解 OSA。然而，其发病机制尚不清楚。我们旨在探讨接受 Roux-en-Y 胃旁路术（RYGB）的患者中 betatrophin 与 OSA 的关系。我们的研究包括 37 名 OSA 合并 2 型糖尿病患者（男 16 例，女 21 例），均接受 RYGB 手术。在 RYGB 手术前后 1 年，进行了多导睡眠图测试、人体测量学结果、血清 betatrophin 和腹部磁共振成像评估。研究了与 OSA 缓解相关的因素。在本研究中，RYGB 手术可显著降低呼吸暂停低通气指数（AHI）和血清 betatrophin 浓度（p<0.001）。腹部内脏脂肪面积、皮下脂肪面积和 HOMA-IR 也显著降低（p<0.001）。术前 AHI、术后 AHI 和 AHI 变化与术前 betatrophin、术后 betatrophin 和 betatrophin 变化均显著相关（p<0.05）。在调整其他危险因素后，这些相关性仍然显著。betatrophin 的变化与最低血氧饱和度的变化也独立相关（p<0.001）。我们的数据可能表明，血清 betatrophin 与减重手术后 OSA 的改善显著独立相关。
