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初始时采用高敏肌钙蛋白T的HEART评分:排除急诊室胸痛患者

The HEART score with high-sensitive troponin T at presentation: ruling out patients with chest pain in the emergency room.

作者信息

Santi Luca, Farina Gabriele, Gramenzi Annagiulia, Trevisani Franco, Baccini Margherita, Bernardi Mauro, Cavazza Mario

机构信息

Department of Emergency, Medicina d'Urgenza e Pronto Soccorso, Policlinico S. Orsola-Malpighi, Alma Mater Studiorum-University of Bologna, Bologna, Italy.

Department of Emergency, Medicina d'Urgenza e Pronto Soccorso, Policlinico S. Orsola-Malpighi, Bologna, Italy.

出版信息

Intern Emerg Med. 2017 Apr;12(3):357-364. doi: 10.1007/s11739-016-1461-3. Epub 2016 May 13.

Abstract

The HEART score is a simple scoring system, ranging from 0 to 10, specifically developed for risk stratification of patients with undifferentiated chest pain. It has been validated for the conventional troponin, but not for high-sensitive troponin. We assess a modified version of the HEART score using a single high-sensitivity troponin T dosage at presentation, regardless of symptom duration, and with different ECG criteria to evaluate if the patients with a low HEART score could be safely discharged early. The secondary aim was to confirm a statistically significant difference in each HEART score group (low 0-3, intermediate 4-6, high 7-10) in the occurrence of major adverse cardiac events at 30 and 180 days. We retrospectively analyzed the HEART score of 1597 consecutive patients admitted to the Emergency Department of our Hospital for chest pain between January 1 and June 30, 2014. Of these, 190 did not meet the inclusion criteria and 29 were lost to follow-up. None of the 512 (37.2 %) patients with a low HEART score had an event within 180 days. The difference between the cumulative incidences of events in the three HEART score groups was statistically significant (P < 0.0001). We demonstrate that it might be possible to safely discharge Emergency Department chest pain patients with a low modified HEART score after an initial determination of high-sensitive troponin T, without a prolonged observation period or an additional cardiac testing.

摘要

HEART评分是一种简单的评分系统,范围从0到10,专为未分化型胸痛患者的风险分层而开发。它已在传统肌钙蛋白方面得到验证,但在高敏肌钙蛋白方面尚未得到验证。我们使用就诊时单次高敏肌钙蛋白T剂量评估改良版的HEART评分,无论症状持续时间如何,并采用不同的心电图标准,以评估低HEART评分的患者是否可以安全地早期出院。次要目的是确认每个HEART评分组(低0 - 3分、中4 - 6分、高7 - 10分)在30天和180天时主要不良心脏事件发生情况的统计学显著差异。我们回顾性分析了2014年1月1日至6月30日期间因胸痛入住我院急诊科的1597例连续患者的HEART评分。其中,190例不符合纳入标准,29例失访。512例(37.2%)低HEART评分患者在180天内均未发生事件。三个HEART评分组事件累积发生率之间的差异具有统计学意义(P < 0.0001)。我们证明,在初步测定高敏肌钙蛋白T后,对于改良HEART评分低的急诊科胸痛患者,可能无需延长观察期或进行额外的心脏检查即可安全出院。

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