Adhikary L P, Pokhrel A, Yadava S K, Khadka D, Thakur R
Division of Nephrology, Department of Internal Medicine, Kathmandu Medical College Teaching Hospital, Sinamangal, Kathmandu, Nepal.
Kathmandu Univ Med J (KUMJ). 2015 Jul-Sep;13(51):220-3. doi: 10.3126/kumj.v13i3.16811.
Background Anemia is a common complication of chronic kidney disease. There are various causes of anemia in chronic kidney disease patients on hemodialysis. Secondary hyperparathyroidism is one of the less recognized causes of anemia in chronic kidney disease patients. Objectives The main objective of the study is to find the correlation between intact parathyroid hormone and hematocrit level in chronic kidney disease (CKD) patients undergoing hemodialysis. Method Verbal consent was taken from all the participants. Eighty participants between the age of 29 and 70 years with chronic kidney disease having indication of hemodialysis were included in this study. Hematocrit was measured by bioelectrical impedance method and serum intact parathyroid hormone was by using Chemi Luminescence Immuno Assay (CLIA) method. Result A weak reverse correlation was found between serum intact parathyroid level and hematocrit (r= -0.33). Conclusion In chronic kidney disease patient, there is reverse correlation between level of serum intact parathyroid and hematocrit level. This association may have clinical relevance in assessing the cause of unexplained low hemoglobin level in CKD patients.
贫血是慢性肾脏病的常见并发症。血液透析的慢性肾脏病患者贫血的病因多种多样。继发性甲状旁腺功能亢进是慢性肾脏病患者贫血的较少被认识的病因之一。
本研究的主要目的是找出接受血液透析的慢性肾脏病（CKD）患者中完整甲状旁腺激素与血细胞比容水平之间的相关性。
获得了所有参与者的口头同意。本研究纳入了80名年龄在29至70岁之间、患有慢性肾脏病且有血液透析指征的参与者。血细胞比容采用生物电阻抗法测量，血清完整甲状旁腺激素采用化学发光免疫分析（CLIA）法测定。
血清完整甲状旁腺水平与血细胞比容之间存在弱负相关（r = -0.33）。
在慢性肾脏病患者中，血清完整甲状旁腺水平与血细胞比容水平呈负相关。这种关联在评估CKD患者不明原因的低血红蛋白水平的病因方面可能具有临床意义。
