含季碳的内炔烃的可见光光氧化还原合成
Visible-light photoredox synthesis of internal alkynes containing quaternary carbons.
作者信息
Gao Chang, Li Jingjing, Yu Jipan, Yang Haijun, Fu Hua
机构信息
Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China.
出版信息
Chem Commun (Camb). 2016 May 26;52(45):7292-4. doi: 10.1039/c6cc01632d.
PMID:27181024
Abstract
A novel and efficient visible-light photoredox method for the synthesis of internal alkynes containing quaternary carbons has been developed via coupling reactions of N-phthalimidoyl oxalates of tert-alcohols with 1-(2-(arylsulfonyl)ethynyl)benzenes. The reactions proceeded well at room temperature with good functional group tolerability.
摘要
通过叔醇的N-邻苯二甲酰亚胺基草酸酯与1-(2-(芳基磺酰基)乙炔基)苯的偶联反应，开发了一种新颖且高效的可见光光氧化还原方法来合成含季碳的内炔。该反应在室温下顺利进行，具有良好的官能团耐受性。
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