孢子丝菌病患者外周血中CD8 + T细胞的百分比更低。

Lower percentage of CD8+ T cells in peripheral blood of patients with sporotrichosis.

作者信息

Zhu Mingji, Xu Yaqin, An Lin, Jiang Jinlan, Zhang Xu, Jiang Rihua

机构信息

Department of Dermatology, China-Japan Union Hospital Of Jilin University, 126 Xiantai St, Erdao, Changchun, Jilin 130033, China.

Research Center, China-Japan Union Hospital of Jilin University, 126 Xiantai St, Erdao, Changchun, Jilin 130033, China.

出版信息

Hum Immunol. 2016 Jul;77(7):576-9. doi: 10.1016/j.humimm.2016.05.008. Epub 2016 May 12.

DOI:10.1016/j.humimm.2016.05.008

PMID:27181291

Abstract

PURPOSE

To characterize the peripheral immunity and immunity response of patients with sporotrichosis, in this study we determined the lymphocyte subsets in the peripheral blood of Chinese patients with sporotrichosis.

METHODS

In this retrospective study, peripheral blood was collected from 69 sporotrichosis patients (37, fixed cutaneous form; 32 lymphocutaneous) and 66 healthy controls. Lymphocyte subsets were analyzed using flow cytometry.

RESULTS

Compared to controls, the percentage of CD8+ T cells was lower in sporotrichosis patients. The percentage of CD8+ T cells in peripheral blood tended to become lower with disease duration and disease severity, although the difference was not statistically significant for either acute, subacute and chronic patients or fixed cutaneous and lymphocutaneous patients.

CONCLUSION

Our data indicate that the decrease of CD8+ T cells in peripheral blood of patients with sporotrichosis is associated with disease severity, although the difference was not statistically significant for either duration or clinical forms of the disease. Combining antifungal agents and immunomodulators in patients with long disease duration and lymphocutaneous may be more beneficial than antifungal monotherapy.

摘要