一名克罗恩病患者中与英夫利昔单抗相关的急性肾小管间质性肾炎
Acute Tubulointerstitial Nephritis Associated with Infliximab in a Patient with Crohn's Disease.
作者信息
Ota Mineto, Iwai Hideyuki, Imai Kaori, Kamiya Mari, Yoshihashi-Nakazato Yoko, Miyasaka Nobuyuki, Kohsaka Hitoshi
机构信息
Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Japan.
出版信息
Intern Med. 2016;55(10):1367-70. doi: 10.2169/internalmedicine.55.5834. Epub 2016 May 15.
We report the findings of a 46-year-old man, who presented with fever and renal dysfunction while undergoing treatment for Crohn's disease with infliximab (IFX). Remittent fever and renal dysfunction with urinary casts developed and lasted for 3 weeks without deterioration of Crohn's disease. Renal biopsy revealed acute tubulointerstitial nephritis (ATIN). After the discontinuation of IFX, his fever and renal abnormalities resolved. We herein report the first known case of ATIN associated with IFX.
我们报告了一名46岁男性的病例，该患者在使用英夫利昔单抗（IFX）治疗克罗恩病期间出现发热和肾功能不全。出现了弛张热和伴有尿沉渣的肾功能不全，持续3周，克罗恩病未恶化。肾活检显示为急性肾小管间质性肾炎（ATIN）。停用IFX后，他的发热和肾脏异常得以缓解。我们在此报告首例已知的与IFX相关的ATIN病例。
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