Jocham D, Baumgartner R, Fuchs N, Lenz H, Stepp H, Unsöld E
Urologische Klinik und Poliklinik LMU München.
Urologe A. 1989 Mar;28(2):59-64.
On the basis of selective storage of fluorescing hematoporphyrin derivative (HpD) in tumors, a method has been developed that enables the endoscopic detection of early-stage cancer by monitoring fluorescent images. The contrast-reducing portion of the superposed tissue autofluorescence is suppressed by the use of two-wavelength excitation and subsequent image processing in realtime. The amount of photosensitizing HpD necessary for diagnostic purposes is considerably reduced by means of sensitive detection devices. A clear distinction between benign and malignant bladder tissue seems possible according to the results of animal studies.
基于荧光血卟啉衍生物（HpD）在肿瘤中的选择性蓄积，已开发出一种通过监测荧光图像进行内镜早期癌症检测的方法。通过双波长激发及后续实时图像处理，可抑制叠加的组织自发荧光中降低对比度的部分。借助灵敏的检测设备，诊断所需的光敏性HpD量大幅减少。根据动物研究结果，良性和恶性膀胱组织似乎有可能得到明确区分。
