D'Hallewin M A, Baert L, Vanherzeele H
Department of Urology, K.U. Leuven, Belgium.
Acta Urol Belg. 1994 Dec;62(4):49-52.
Fluorescence tagging of tumors by sensitizing agents such as hematoporphyrin derivatives is an efficient method for diagnosing tumors but presents, even at low doses, a number of serious drawbacks for the patients. We demonstrate a fiberoptic instrument for the diagnosis of bladder cancer, based on a tripled frequency Nd YAG laser, without need for sensitizing agents, based on the autofluorescence of tissues. The contrast demarcation obtained for CIS and TCC respectively is 2.2 and 2.7, which is about 30% higher than what can be obtained after photosensitizing. The integration of the diagnostic method with a reliable therapeutic technique for tumor cell destruction, opens the way for cost-effective preventive care of high risk patients.
通过血卟啉衍生物等敏化剂对肿瘤进行荧光标记是一种有效的肿瘤诊断方法，但即便使用低剂量，对患者而言仍存在诸多严重缺点。我们展示了一种基于三倍频钕钇铝石榴石激光的用于诊断膀胱癌的光纤仪器，该仪器基于组织的自发荧光，无需敏化剂。原位癌（CIS）和移行细胞癌（TCC）分别获得的对比度分界为2.2和2.7，比光敏化后所能获得的对比度约高30%。将该诊断方法与可靠的肿瘤细胞破坏治疗技术相结合，为高危患者的经济高效预防护理开辟了道路。
