牛免疫球蛋白E的初乳转移及犊牛血清IgE的动态变化
Colostral transfer of bovine immunoglobulin E and dynamics of serum IgE in calves.
作者信息
Thatcher E F, Gershwin L J
机构信息
Department of Veterinary Microbiology and Immunology, School of Veterinary Medicine, University of California, Davis 95616.
出版信息
Vet Immunol Immunopathol. 1989 Mar;20(4):325-34. doi: 10.1016/0165-2427(89)90078-0.
The role of IgE in protective immunity is becoming understood, therefore the colostral transfer of IgE and the age-dependent changes of IgE levels may be important for neonatal immunity. To investigate this question, serum samples were collected from range-fed Hereford cows and their calves from birth through 9 months of age. The sera were assayed for total IgE during the first week postpartum, indicating colostral transfer of IgE. Thereafter, serum levels declined rapidly within 3 weeks from birth. The IgE levels began to increase after 12 weeks of age, and in some cases reached adult levels. The passive transfer of maternal IgE through colostrum may be important in providing early protection from disease, especially against intestinal parasites.
IgE在保护性免疫中的作用正逐渐被人们所了解，因此，初乳中IgE的传递以及IgE水平随年龄的变化可能对新生儿免疫至关重要。为了研究这个问题，从出生到9月龄，采集了放牧饲养的赫里福德奶牛及其犊牛的血清样本。在产后第一周对血清进行总IgE检测，以表明IgE的初乳传递情况。此后，出生后3周内血清水平迅速下降。IgE水平在12周龄后开始上升，在某些情况下达到成年水平。母体IgE通过初乳的被动传递在提供早期疾病防护方面可能很重要，尤其是针对肠道寄生虫。
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