人乳头瘤病毒最新情况：疫苗接种、筛查及相关疾病
HPV Update: Vaccination, Screening, and Associated Disease.
作者信息
McNamara Megan, Batur Pelin, Walsh Judith M E, Johnson Kay M
机构信息
Department of Medicine, Case Western Reserve University School of Medicine and Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA.
Department of Medicine and Primary Care Women's Health, Cleveland Clinic, Cleveland, OH, USA.
出版信息
J Gen Intern Med. 2016 Nov;31(11):1360-1366. doi: 10.1007/s11606-016-3725-z. Epub 2016 May 16.
Abstract
Human papillomavirus (HPV) infection is the causative agent in cervical cancer, and is associated with numerous other genital cancers, including vulvar, vaginal, and anal cancer. Primary prevention with HPV vaccination is safe and efficacious, and a recently approved HPV vaccine will provide even more extensive protection against several oncogenic HPV strains. Screening strategies for HPV are rapidly evolving, reflecting the essential role that HPV infection plays in cervical cancer. This article highlights new evidence regarding the efficacy of the recently approved 9-valent HPV (9vHPV) vaccine and the use of primary high-risk HPV testing in cervical cancer screening. We consider the utility of urinary HPV testing in routine clinical practice and review current guidelines regarding anal HPV screening.
摘要
人乳头瘤病毒（HPV）感染是宫颈癌的致病因素，并且与包括外阴癌、阴道癌和肛门癌在内的许多其他生殖器癌症相关。HPV疫苗接种的一级预防是安全有效的，并且一种最近获批的HPV疫苗将提供针对几种致癌性HPV毒株的更广泛保护。HPV的筛查策略正在迅速发展，这反映了HPV感染在宫颈癌中所起的重要作用。本文重点介绍了有关最近获批的9价HPV（9vHPV）疫苗效力以及在宫颈癌筛查中使用一级高危HPV检测的新证据。我们考虑了尿液HPV检测在常规临床实践中的实用性，并回顾了有关肛门HPV筛查的现行指南。
相似文献
1
HPV Update: Vaccination, Screening, and Associated Disease.人乳头瘤病毒最新情况：疫苗接种、筛查及相关疾病
J Gen Intern Med. 2016 Nov;31(11):1360-1366. doi: 10.1007/s11606-016-3725-z. Epub 2016 May 16.
2
Human papillomavirus prevalence and type-distribution, cervical cancer screening practices and current status of vaccination implementation in Central and Eastern Europe.人乳头瘤病毒流行率和型别分布、在中欧和东欧的宫颈癌筛查做法以及当前疫苗接种实施状况。
Vaccine. 2013 Dec 31;31 Suppl 7:H59-70. doi: 10.1016/j.vaccine.2013.03.029.
3
Comprehensive control of human papillomavirus infections and related diseases.人乳头瘤病毒感染及相关疾病的综合防控。
Vaccine. 2013 Nov 22;31 Suppl 8(0 8):I1-31. doi: 10.1016/j.vaccine.2013.07.026.
4
Human papillomavirus prevalence and type-distribution, cervical cancer screening practices and current status of vaccination implementation in Russian Federation, the Western countries of the former Soviet Union, Caucasus region and Central Asia.人乳头瘤病毒在俄罗斯联邦、前苏联西方国家、高加索地区和中亚的流行情况和型别分布、宫颈癌筛查实践以及疫苗接种实施现状。
Vaccine. 2013 Dec 31;31 Suppl 7:H46-58. doi: 10.1016/j.vaccine.2013.06.043.
5
Cervical cancer screening of HPV vaccinated populations: Cytology, molecular testing, both or none.人乳头瘤病毒疫苗接种人群的宫颈癌筛查：细胞学检查、分子检测、两者皆用或两者皆不用。
J Clin Virol. 2016 Mar;76 Suppl 1(Suppl 1):S62-S68. doi: 10.1016/j.jcv.2015.11.020. Epub 2015 Nov 18.
6
Prevention of human papillomavirus (HPV)-related tumors in people living with human immunodeficiency virus (HIV).预防人免疫缺陷病毒（HIV）感染者的人乳头瘤病毒（HPV）相关肿瘤。
Expert Rev Anti Infect Ther. 2017 Nov;15(11):987-999. doi: 10.1080/14787210.2017.1392854. Epub 2017 Oct 20.
7
Quadrivalent Human Papillomavirus Vaccine: Recommendations of the Advisory Committee on Immunization Practices (ACIP).四价人乳头瘤病毒疫苗：免疫实践咨询委员会（ACIP）的建议
MMWR Recomm Rep. 2007 Mar 23;56(RR-2):1-24.
8
Comprehensive control of human papillomavirus infections and related diseases.人乳头瘤病毒感染及相关疾病的综合防控。
Vaccine. 2013 Dec 29;31 Suppl 5:F1-31. doi: 10.1016/j.vaccine.2013.10.001.
9
Public health impact and cost effectiveness of routine and catch-up vaccination of girls and women with a nine-valent HPV vaccine in Japan: a model-based study.在日本，九价 HPV 疫苗对女童和妇女进行常规和补种接种的公共卫生影响和成本效益：基于模型的研究。
BMC Infect Dis. 2021 Jan 6;21(1):11. doi: 10.1186/s12879-020-05632-0.
10
Infrastructure requirements for human papillomavirus vaccination and cervical cancer screening in sub-Saharan Africa.撒哈拉以南非洲地区人乳头瘤病毒疫苗接种和宫颈癌筛查的基础设施要求。
Vaccine. 2013 Dec 29;31 Suppl 5:F47-52. doi: 10.1016/j.vaccine.2012.06.066.
引用本文的文献
1
The Impact of a Human Papillomavirus Facebook-Based Intervention (#HPVVaxTalks) Among Young Black (African American and Sub-Saharan African Immigrants) Adults: Pilot Pre- and Poststudy.基于脸书的人乳头瘤病毒干预措施（#HPVVaxTalks）对年轻黑人（非裔美国人和撒哈拉以南非洲移民）成年人的影响：预研究和后研究试点
JMIR Form Res. 2025 Apr 2;9:e69609. doi: 10.2196/69609.
2
Decoding impact of human papillomavirus in gynecological oncology: a narrative review.解读人乳头瘤病毒在妇科肿瘤学中的影响：一项叙述性综述
Obstet Gynecol Sci. 2025 Jan;68(1):30-42. doi: 10.5468/ogs.24226. Epub 2025 Jan 9.
3
A novel therapeutic multiepitope vaccine based on oncoprotein E6 and E7 of HPV 16 and 18: An approach.一种基于人乳头瘤病毒16型和18型癌蛋白E6和E7的新型治疗性多表位疫苗：一种方法。
Bioimpacts. 2024;14(5):27846. doi: 10.34172/bi.2024.27846. Epub 2024 Feb 6.
4
Longitudinal Screening for Oral High-Risk Non-HPV16 and Non-HPV18 Strains of Human Papillomavirus Reveals Increasing Prevalence among Adult and Pediatric Biorepository Samples: A Pilot Study.人乳头瘤病毒口腔高危非HPV16和非HPV18毒株的纵向筛查显示，成人和儿童生物样本库样本中的患病率呈上升趋势：一项试点研究。
Vaccines (Basel). 2024 Aug 8;12(8):895. doi: 10.3390/vaccines12080895.
5
Maternal HPV Infection: Effects on Pregnancy Outcome.母体人乳头瘤病毒感染：对妊娠结局的影响。
Viruses. 2021 Dec 7;13(12):2455. doi: 10.3390/v13122455.
6
Current update on vaginal malignancies.阴道恶性肿瘤的最新进展
Abdom Radiol (NY). 2021 Nov;46(11):5353-5368. doi: 10.1007/s00261-021-03228-z. Epub 2021 Aug 2.
7
Epidemiology and Burden of Human Papillomavirus and Related Diseases, Molecular Pathogenesis, and Vaccine Evaluation.人乳头瘤病毒及相关疾病的流行病学和负担、分子发病机制和疫苗评估。
Front Public Health. 2021 Jan 20;8:552028. doi: 10.3389/fpubh.2020.552028. eCollection 2020.
8
Cancer Prevention by Natural Products Introduced into the Diet-Selected Cyclitols.天然产物在饮食中的引入对癌症的预防作用-选择环糖醇。
Int J Mol Sci. 2020 Nov 26;21(23):8988. doi: 10.3390/ijms21238988.
9
Misinformation, Gendered Perceptions, and Low Healthcare Provider Communication Around HPV and the HPV Vaccine Among Young Sexual Minority Men in New York City: The P18 Cohort Study.HPV 及 HPV 疫苗相关的错误信息、性别认知差异，以及医疗服务提供者沟通不足：纽约年轻性少数男性群体（P18 队列研究）。
J Community Health. 2020 Aug;45(4):702-711. doi: 10.1007/s10900-019-00784-w.
10
Detection of precancerous lesions in the cervix and HPV infection in women in the region of Maniapure, Bolivar State.玻利瓦尔州马尼亚普尔地区女性子宫颈癌前病变及人乳头瘤病毒感染的检测
Ecancermedicalscience. 2018 Dec 3;12:884. doi: 10.3332/ecancer.2018.884. eCollection 2018.
本文引用的文献
1
Health and Economic Impact of Switching from a 4-Valent to a 9-Valent HPV Vaccination Program in the United States.美国从四价人乳头瘤病毒疫苗接种计划转换为九价人乳头瘤病毒疫苗接种计划对健康和经济的影响。
J Natl Cancer Inst. 2015 Oct 4;108(1). doi: 10.1093/jnci/djv282. Print 2016 Jan.
2
National, Regional, State, and Selected Local Area Vaccination Coverage Among Adolescents Aged 13-17 Years--United States, 2014.2014年美国13至17岁青少年的全国、地区、州及部分局部地区疫苗接种覆盖率
MMWR Morb Mortal Wkly Rep. 2015 Jul 31;64(29):784-92. doi: 10.15585/mmwr.mm6429a3.
3
Sexually transmitted diseases treatment guidelines, 2015.《2015年性传播疾病治疗指南》
MMWR Recomm Rep. 2015 Jun 5;64(RR-03):1-137.
4
Cervical Cancer Screening in Average-Risk Women: Best Practice Advice From the Clinical Guidelines Committee of the American College of Physicians.美国医师学院临床指南委员会关于普通风险女性的宫颈癌筛查：最佳实践建议。
Ann Intern Med. 2015 Jun 16;162(12):851-9. doi: 10.7326/M14-2426.
5
Cervical cancer prevention: immunization and screening 2015.宫颈癌预防：免疫接种和筛查 2015 年版。
Med Clin North Am. 2015 May;99(3):469-77. doi: 10.1016/j.mcna.2015.01.003. Epub 2015 Feb 28.
6
Use of 9-valent human papillomavirus (HPV) vaccine: updated HPV vaccination recommendations of the advisory committee on immunization practices.九价人乳头瘤病毒（HPV）疫苗的使用：免疫实践咨询委员会的HPV疫苗接种最新建议
MMWR Morb Mortal Wkly Rep. 2015 Mar 27;64(11):300-4.
7
Prevalence of anal human papillomavirus infection and anal HPV-related disorders in women: a systematic review.女性肛门人乳头瘤病毒感染及肛门HPV相关疾病的患病率：一项系统评价
Am J Obstet Gynecol. 2015 Sep;213(3):278-309. doi: 10.1016/j.ajog.2015.03.034. Epub 2015 Mar 19.
8
A 9-valent HPV vaccine against infection and intraepithelial neoplasia in women.九价人乳头瘤病毒疫苗预防女性感染和上皮内瘤变。
N Engl J Med. 2015 Feb 19;372(8):711-23. doi: 10.1056/NEJMoa1405044.
9
Primary cervical cancer screening with human papillomavirus: end of study results from the ATHENA study using HPV as the first-line screening test.人乳头瘤病毒用于宫颈癌一线筛查的 ATHENA 研究：研究结束时的结果
Gynecol Oncol. 2015 Feb;136(2):189-97. doi: 10.1016/j.ygyno.2014.11.076. Epub 2015 Jan 8.
10
Use of primary high-risk human papillomavirus testing for cervical cancer screening: interim clinical guidance.原发性高危型人乳头瘤病毒检测用于宫颈癌筛查：临时临床指南
Obstet Gynecol. 2015 Feb;125(2):330-337. doi: 10.1097/AOG.0000000000000669.
Zotero 插件