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人乳头瘤病毒最新情况:疫苗接种、筛查及相关疾病

HPV Update: Vaccination, Screening, and Associated Disease.

作者信息

McNamara Megan, Batur Pelin, Walsh Judith M E, Johnson Kay M

机构信息

Department of Medicine, Case Western Reserve University School of Medicine and Louis Stokes Cleveland Veterans Affairs Medical Center, 10701 East Boulevard, Cleveland, OH, 44106, USA.

Department of Medicine and Primary Care Women's Health, Cleveland Clinic, Cleveland, OH, USA.

出版信息

J Gen Intern Med. 2016 Nov;31(11):1360-1366. doi: 10.1007/s11606-016-3725-z. Epub 2016 May 16.

Abstract

Human papillomavirus (HPV) infection is the causative agent in cervical cancer, and is associated with numerous other genital cancers, including vulvar, vaginal, and anal cancer. Primary prevention with HPV vaccination is safe and efficacious, and a recently approved HPV vaccine will provide even more extensive protection against several oncogenic HPV strains. Screening strategies for HPV are rapidly evolving, reflecting the essential role that HPV infection plays in cervical cancer. This article highlights new evidence regarding the efficacy of the recently approved 9-valent HPV (9vHPV) vaccine and the use of primary high-risk HPV testing in cervical cancer screening. We consider the utility of urinary HPV testing in routine clinical practice and review current guidelines regarding anal HPV screening.

摘要

人乳头瘤病毒(HPV)感染是宫颈癌的致病因素,并且与包括外阴癌、阴道癌和肛门癌在内的许多其他生殖器癌症相关。HPV疫苗接种的一级预防是安全有效的,并且一种最近获批的HPV疫苗将提供针对几种致癌性HPV毒株的更广泛保护。HPV的筛查策略正在迅速发展,这反映了HPV感染在宫颈癌中所起的重要作用。本文重点介绍了有关最近获批的9价HPV(9vHPV)疫苗效力以及在宫颈癌筛查中使用一级高危HPV检测的新证据。我们考虑了尿液HPV检测在常规临床实践中的实用性,并回顾了有关肛门HPV筛查的现行指南。

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