腮腺癌患者中淋巴结比率对预后的预测
Prediction of outcome by lymph node ratio in patients with parotid gland cancer.
作者信息
Meyer M F, Kreppel M, Meinrath J, Grünewald I, Stenner M, Drebber U, Quaas A, Odenthal M, Semrau R, Huebbers C U, Zöller J, Huettenbrink K-B, Buettner R, Beutner D
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, University of Cologne, Cologne, Germany.
Department for Oral and Maxillofacial Plastic Surgery, University of Cologne, Cologne, Germany.
出版信息
Clin Otolaryngol. 2017 Feb;42(1):98-103. doi: 10.1111/coa.12672. Epub 2016 May 30.
OBJECTIVE
Lymph node ratio (LNR) has been shown to be an independent predictor of recurrence risk and survival in different entities of carcinoma.
METHODS
In this retrospective chart review, 128 patients with parotid gland cancer (PGC) subsequently treated by primary surgery were included. About 64% (n = 82) of these patients were additionally treated with adjuvant radiotherapy. Five-year overall survival rates were determined by subgroups based on LNR value.
RESULTS
Lymph node ratio was found to be significantly associated with overall survival rate (P < 0.001). Using univariate analyses, pathological tumour-node-metastasis (TNM)-stage, UICC-stage grouping and extracapsular spread were found to be significant predictors of overall survival (P < 0.001). However, with a multivariate analyses, LNR remained the only independent predictor of overall survival (P = 0.043).
CONCLUSIONS
After surgery for PGC, evaluation of the neck using LNR was found to reliably stratify the overall survival rate.
目的
淋巴结比率（LNR）已被证明是不同类型癌症复发风险和生存的独立预测指标。
方法
在这项回顾性病历审查中，纳入了128例随后接受原发手术治疗的腮腺癌（PGC）患者。其中约64%（n = 82）的患者还接受了辅助放疗。根据LNR值将患者分为不同亚组，确定其5年总生存率。
结果
发现淋巴结比率与总生存率显著相关（P < 0.001）。单因素分析显示，病理肿瘤-淋巴结-转移（TNM）分期、国际抗癌联盟（UICC）分期分组和包膜外扩散是总生存的显著预测因素（P < 0.001）。然而，多因素分析显示，LNR仍然是总生存的唯一独立预测因素（P = 0.043）。
结论
PGC手术后，通过LNR评估颈部情况可可靠地对总生存率进行分层。
Zotero 插件