Katsushima Hiroki, Fukuhara Noriko, Ichikawa Satoshi, Ota Yasunori, Takeuchi Kengo, Ishizawa Kenichi, Sasano Hironobu, Harigae Hideo, Ichinohasama Ryo
a Division of Hematopathology , Tohoku University Hospital , Sendai , Japan.
b Department of Anatomic Pathology , Tohoku University Graduate School of Medicine , Sendai , Japan.
Leuk Lymphoma. 2017 Jan;58(1):80-88. doi: 10.1080/10428194.2016.1183254. Epub 2016 May 17.
Previous worldwide epidemiological studies on lymphoid leukemia and/or lymphoma (LL/L) had considerable bias because of difficulty in covering all clinical departments of hospitals in a restricted area (population base). These studies may not have reflected the actual number of newly diagnosed cases (incidence) strictly, or the true LL/L subtype frequencies. We searched all cases of newly diagnosed LL/L in Miyagi Prefecture over a 5-year period, including those that were discovered as LL/L sorely after autopsy. We registered the actual number of 2098 cases in the prefecture and calculated an accurate incidence rate (17.8 per 100,000 persons). Additionally, we identified more realistic and detailed frequencies of LL/L subtypes including the leukemic phase of some lymphomas. As Miyagi Prefecture is an area in which the population dynamics are relatively stable and representative of Japan, the result of our epidemiological study can be used as the first representative index of LL/L for Japan.
以往关于淋巴样白血病和/或淋巴瘤（LL/L）的全球流行病学研究存在相当大的偏差，原因在于在有限区域（人口基数）内难以涵盖医院的所有临床科室。这些研究可能并未严格反映新诊断病例的实际数量（发病率），也未反映LL/L的真实亚型频率。我们对宫城县5年内所有新诊断的LL/L病例进行了检索，包括那些仅在尸检后才被确认为LL/L的病例。我们记录了该县2098例病例的实际数量，并计算出准确的发病率（每10万人中17.8例）。此外，我们确定了更符合实际且更详细的LL/L亚型频率，包括一些淋巴瘤的白血病期。由于宫城县是一个人口动态相对稳定且具有日本代表性的地区，我们的流行病学研究结果可作为日本LL/L的首个代表性指标。
