[齐多夫定引起的指甲色素沉着]
[Nail pigmentation caused by azidothymidine].
作者信息
Depaoli M A, Bedello P G, Tamponi M
出版信息
G Ital Dermatol Venereol. 1989 Mar;124(3):71-2.
PMID:2807386
Abstract
Azidothymidine is a new antiviral drug that acts by competitive inhibition of reverse transcriptase of retroviruses. Azidothymidine is now widely used in treatment of patients with AIDS or ARC; the most important side effects of this drug are anaemia and neutropenia. Recently pigmentary changes of the nails (diffuse pigmentation and longitudinal or transverse bands) provoked by azidothymidine-treatment have also been reported. We describe a such case.
摘要
叠氮胸苷是一种新型抗病毒药物，其作用机制是竞争性抑制逆转录病毒的逆转录酶。叠氮胸苷目前广泛用于治疗艾滋病或艾滋病相关综合征患者；该药物最重要的副作用是贫血和中性粒细胞减少。最近也有报道称，叠氮胸苷治疗会引发指甲色素沉着改变（弥漫性色素沉着以及纵向或横向条纹）。我们描述了这样一个病例。
相似文献
1
[Nail pigmentation caused by azidothymidine].[齐多夫定引起的指甲色素沉着]
G Ital Dermatol Venereol. 1989 Mar;124(3):71-2.
2
[Striated nail discoloration caused by zidovudine].[齐多夫定引起的横纹状指甲变色]
Z Hautkr. 1989 Feb 15;64(2):91-5.
3
Azidothymidine-induced hyperpigmentation of skin and nails.齐多夫定引起的皮肤和指甲色素沉着过度。
Arch Dermatol. 1989 Sep;125(9):1285-6.
4
Pigmented nail bands and mucocutaneous pigmentation in HIV-positive patients treated with zidovudine.接受齐多夫定治疗的HIV阳性患者出现的色素沉着指甲带和黏膜皮肤色素沉着。
J Am Acad Dermatol. 1990 Apr;22(4):687-8. doi: 10.1016/s0190-9622(08)81046-8.
5
Azidothymidine-induced nail pigmentation.齐多夫定引起的指甲色素沉着。
Cutis. 1989 Jun;43(6):552-4.
6
Longitudinal melanonychia induced by 3'-azidodeoxythymidine. Report of 9 cases.3'-叠氮脱氧胸苷诱发的纵向黑甲。9例报告。
Dermatologica. 1990;180(4):217-20.
7
[Bluish pigmentation of the nails in AIDS patients. Possibly an adverse effect of Zidovudine?].[艾滋病患者指甲的蓝色色素沉着。可能是齐多夫定的不良反应？]
Rev Clin Esp. 1988 Oct;183(5):278-9.
8
9
Nail pigmentation associated with zidovudine: a review and report of a case.齐多夫定相关的指甲色素沉着：病例报告及文献综述
Scand J Infect Dis. 1992;24(5):557-61. doi: 10.3109/00365549209054640.
10
[Ungual pigmentation in patients with AIDS treated with zidovudine].[接受齐多夫定治疗的艾滋病患者的指甲色素沉着]
Rev Clin Esp. 1990 Jun;187(2):94.
Zotero 插件