Zotz R, Duwe L, Erbel R, Frank P, Brennecke R, Meyer J
II. Med. Klinik und Poliklinik, Johannes-Gutenberg-Universität, Mainz.
Z Kardiol. 1989 Feb;78(2):95-100.
Forty patients (14 women, 26 men, mean age 58 years) with suspected anomaly of the right heart and suspected tricuspid insufficiency or atrial septal defect were given four injections of Gelifundol in five-minute intervals via the right cubital vein. Before, during, and after each injection an echocardiogram was obtained (four-chamber-view). One subcostal view was recorded. Contrast echocardiograms were analyzed according to a subjective score scheme by two independent observers and by video-intensitometry. After injection of contrast medium no patient showed ECG changes, nor did any patient report side effects after the injection of Gelifundol. Concerning the subjective parameters there were no significant differences between both observers. Score points varied between 5.2 to 5.5, intensitometric maxima lay between 54.6 and 58.0 relative intensity units, and the half-time of the intensity maximum (T1/2) varied between 7.2 s and 8.1 s. There were no statistical differences between the two observers. In all patients a diagnotic improvement could be achieved. A tricuspid insufficiency which was not diagnosed in the native echocardiogram could be diagnosed in 13 patients with Gelfundol. Thus, Gelifundol seems well suited for the assessment of right ventricular lesions in man.
40例疑似右心异常及疑似三尖瓣关闭不全或房间隔缺损的患者（14名女性，26名男性，平均年龄58岁）通过右肘静脉每隔5分钟注射4次声诺维。每次注射前、注射期间及注射后均进行超声心动图检查（四腔心视图）。记录一个肋下视图。由两名独立观察者根据主观评分方案并通过视频密度测定法分析对比超声心动图。注射造影剂后，无患者出现心电图改变，注射声诺维后也无患者报告有副作用。关于主观参数，两名观察者之间无显著差异。评分在5.2至5.5之间，密度测定最大值在54.6至58.0相对强度单位之间，强度最大值的半衰期（T1/2）在7.2秒至8.1秒之间。两名观察者之间无统计学差异。所有患者均实现了诊断改善。13例患者通过声诺维诊断出了在未注射造影剂的超声心动图中未诊断出的三尖瓣关闭不全。因此，声诺维似乎非常适合评估人类右心室病变。
