Lynch Jennifer R, Wang Jenny Yingzi
Cancer and Stem Cell Biology Group, Children's Cancer Institute, Lowy Cancer Research Centre, University of New South Wales, Sydney, NSW 2052, Australia.
Centre for Childhood Cancer Research, Faculty of Medicine, University of New South Wales, Sydney, NSW 2052, Australia.
Int J Mol Sci. 2016 May 11;17(5):707. doi: 10.3390/ijms17050707.
G protein-coupled receptors (GPCRs) are a large superfamily of cell-surface signaling proteins that bind extracellular ligands and transduce signals into cells via heterotrimeric G proteins. GPCRs are highly tractable drug targets. Aberrant expression of GPCRs and G proteins has been observed in various cancers and their importance in cancer stem cells has begun to be appreciated. We have recently reported essential roles for G protein-coupled receptor 84 (GPR84) and G protein subunit Gαq in the maintenance of cancer stem cells in acute myeloid leukemia. This review will discuss how GPCRs and G proteins regulate stem cells with a focus on cancer stem cells, as well as their implications for the development of novel targeted cancer therapies.
G蛋白偶联受体(GPCRs)是一类庞大的细胞表面信号蛋白超家族,它们结合细胞外配体,并通过异源三聚体G蛋白将信号传导至细胞内。GPCRs是极易处理的药物靶点。在各种癌症中均观察到GPCRs和G蛋白的异常表达,并且它们在癌症干细胞中的重要性已开始得到认可。我们最近报道了G蛋白偶联受体84(GPR84)和G蛋白亚基Gαq在急性髓系白血病癌症干细胞维持中的重要作用。本综述将讨论GPCRs和G蛋白如何调节干细胞,重点是癌症干细胞,以及它们对新型靶向癌症治疗开发的意义。