Myosin light chain phosphorylation, novel targets to repair a broken heart?
作者信息
Szczesna-Cordary Danuta, de Tombe Pieter P
机构信息
Department of Molecular and Cellular Pharmacology, University of Miami Miller School of Medicine, Miami, FL 33136, USA
Department of Cell and Molecular Physiology, Loyola University, Chicago, IL 60153, USA.
出版信息
Cardiovasc Res. 2016 Jul 1;111(1):5-7. doi: 10.1093/cvr/cvw098. Epub 2016 May 17.
Abstract
摘要
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Acute heart failure with cardiomyocyte atrophy induced in adult mice by ablation of cardiac myosin light chain kinase.通过消融心肌肌球蛋白轻链激酶在成年小鼠中诱导的伴有心肌细胞萎缩的急性心力衰竭。
Cardiovasc Res. 2016 Jul 1;111(1):34-43. doi: 10.1093/cvr/cvw069. Epub 2016 Mar 29.
2
Essential light chain S195 phosphorylation is required for cardiac adaptation under physical stress.必需轻链 S195 磷酸化是物理应激下心脏适应所必需的。
Cardiovasc Res. 2016 Jul 1;111(1):44-55. doi: 10.1093/cvr/cvw066. Epub 2016 Mar 24.
3
Molecular mechanisms of cardiomyopathy phenotypes associated with myosin light chain mutations.与肌球蛋白轻链突变相关的心肌病表型的分子机制
J Muscle Res Cell Motil. 2015 Dec;36(6):433-45. doi: 10.1007/s10974-015-9423-3. Epub 2015 Sep 18.
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Constitutive phosphorylation of cardiac myosin regulatory light chain prevents development of hypertrophic cardiomyopathy in mice.心肌肌球蛋白调节轻链的组成型磷酸化可预防小鼠肥厚型心肌病的发生。
Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4138-46. doi: 10.1073/pnas.1505819112. Epub 2015 Jun 29.
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Myosin light chain phosphorylation is critical for adaptation to cardiac stress.肌球蛋白轻链磷酸化对于适应心脏应激至关重要。
Circulation. 2012 Nov 27;126(22):2575-88. doi: 10.1161/CIRCULATIONAHA.112.116202. Epub 2012 Oct 24.
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Mouse and computational models link Mlc2v dephosphorylation to altered myosin kinetics in early cardiac disease.鼠和计算模型将 Mlc2v 去磷酸化与早期心脏疾病中肌球蛋白动力学的改变联系起来。
J Clin Invest. 2012 Apr;122(4):1209-21. doi: 10.1172/JCI61134. Epub 2012 Mar 19.
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Signaling to myosin regulatory light chain in sarcomeres.肌球蛋白调节轻链在肌节中的信号转导。
J Biol Chem. 2011 Mar 25;286(12):9941-7. doi: 10.1074/jbc.R110.198697. Epub 2011 Jan 21.
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Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo.肌球蛋白轻链激酶对于肌球蛋白调节轻链磷酸化和体内心功能是必需的。
J Biol Chem. 2010 Dec 24;285(52):40819-29. doi: 10.1074/jbc.M110.160499. Epub 2010 Oct 13.
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A single serine in the carboxyl terminus of cardiac essential myosin light chain-1 controls cardiomyocyte contractility in vivo.心脏必需肌球蛋白轻链-1羧基末端的单个丝氨酸在体内控制心肌细胞收缩性。
Circ Res. 2009 Mar 13;104(5):650-9. doi: 10.1161/CIRCRESAHA.108.186676. Epub 2009 Jan 22.
10
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation.小鼠心室肌球蛋白调节轻链磷酸化的消融导致原位心脏功能障碍，并影响相邻肌丝蛋白的磷酸化。
J Biol Chem. 2009 Feb 20;284(8):5097-106. doi: 10.1074/jbc.M807414200. Epub 2008 Dec 23.
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