Vracko R, Thorning D, Frederickson R G
Laboratory Service, VA Medical Center, Seattle, Washington 98108.
Am J Pathol. 1989 May;134(5):993-1006.
To better understand the tendency of myocardium to heal by scarring rather than regeneration, the authors examined the responses of connective tissue cells (CTCs) after three types of necrotizing injuries. Derived from myocardial interstitial cells, CTCs proliferated in both the connective tissue space and the compartment of necrotic myocytes. They assumed various cell forms: fibrocytelike CTCs throughout the sites of injury deposited extracellular scar tissue elements, established CTC-myocyte contacts, and helped anchor myocytes to scar tissue with myotendonlike specializations; CTCs with more complex forms established CTC-myocyte relationships, suggesting important roles in communication and tissue remodeling. CTCs within scar tissue differentiated into myofibrocytes, chondrocytes, and possibly smooth muscle cells. Most scar tissue elements were disposed in the long axis of myocytes. These alterations in form indicate that CTCs have various roles in myocardial repair and suggest that a number of the roles are modulated by contractile forces.
为了更好地理解心肌通过瘢痕形成而非再生进行愈合的倾向，作者研究了三种坏死性损伤后结缔组织细胞（CTCs）的反应。CTCs源自心肌间质细胞，在结缔组织间隙和坏死心肌细胞区域均有增殖。它们呈现出多种细胞形态：在整个损伤部位，纤维样CTCs沉积细胞外瘢痕组织成分，建立CTCs与心肌细胞的接触，并通过类似肌腱的特化结构将心肌细胞锚定到瘢痕组织上；形态更为复杂的CTCs建立了CTCs与心肌细胞的关系，表明其在通讯和组织重塑中发挥重要作用。瘢痕组织内的CTCs分化为肌成纤维细胞、软骨细胞，可能还有平滑肌细胞。大多数瘢痕组织成分沿心肌细胞的长轴排列。这些形态上的改变表明CTCs在心肌修复中具有多种作用，并且提示许多作用受收缩力调节。
