Department of Chemistry, University of Massachusetts-Amherst , 710 North Pleasant Street, Amherst, Massachusetts 01003, United States.
Biological Engineering Program, Faculty of Engineering, King Mongkut's University of Technology Thonburi , Bangmod, Bangkok 10140, Thailand.
ACS Appl Mater Interfaces. 2016 Jun 8;8(22):14096-101. doi: 10.1021/acsami.6b02548. Epub 2016 May 26.
Gold nanoparticles provide an excellent platform for biological and material applications due to their unique physical and chemical properties. However, decreased colloidal stability and formation of irreversible aggregates while freeze-drying nanomaterials limit their use in real world applications. Here, we report a new generation of surface ligands based on a combination of short oligo (ethylene glycol) chains and zwitterions capable of providing nonfouling characteristics while maintaining colloidal stability and functionalization capabilities. Additionally, conjugation of these gold nanoparticles with avidin can help the development of a universal toolkit for further functionalization of nanomaterials.
金纳米颗粒由于其独特的物理和化学性质,为生物和材料应用提供了极好的平台。然而,在冷冻干燥纳米材料时,胶体稳定性下降和不可逆聚集的形成限制了它们在实际应用中的使用。在这里,我们报告了新一代基于短聚乙二醇链和两性离子组合的表面配体,能够提供抗污特性,同时保持胶体稳定性和功能化能力。此外,将这些金纳米颗粒与亲和素偶联可以帮助开发通用工具包,进一步实现纳米材料的功能化。