Aubuchon Mira, Liu Ying, Petroski Gregory F, Thomas Tom R, Polotsky Alex J
a Department of Obstetrics and Gynecology , University of Missouri , Columbia , Missouri , USA.
b Department of Nutrition and Exercise Physiology , University of Missouri , Columbia , Missouri , USA.
Syst Biol Reprod Med. 2016 Aug;62(4):283-9. doi: 10.1080/19396368.2016.1177619. Epub 2016 May 18.
What is the impact of intentional weight loss and regain on serum androgens in women? We conducted an ancillary analysis of prospectively collected samples from a randomized controlled trial. The trial involved supervised 10% weight loss (8.5 kg on average) with diet and exercise over 4-6 months followed by supervised intentional regain of 50% of the lost weight (4.6 kg on average) over 4-6 months. Participants were randomized prior to the partial weight regain component to either continuation or cessation of endurance exercise. Analytic sample included 30 obese premenopausal women (mean age of 40 ± 5.9 years, mean baseline body mass index (BMI) of 32.9 ± 4.2 kg/m(2)) with metabolic syndrome. We evaluated sex hormone binding globulin (SHBG), total testosterone (T), free androgen index (FAI), and high molecular weight adiponectin (HMWAdp). Insulin, homeostasis model assessment (HOMA), and quantitative insulin sensitivity check index (QUICKI), and visceral adipose tissue (VAT) measured in the original trial were reanalyzed for the current analytic sample. Insulin, HOMA, and QUICKI improved with weight loss and were maintained despite weight regain. Log-transformed SHBG significantly increased from baseline to weight loss, and then significantly decreased with weight regain. LogFAI and logVAT decreased similarly and increased with weight loss followed by weight regain. No changes were found in logT and LogHMWAdp. There was no significant difference in any tested parameters by exercise between the groups. SHBG showed prominent sensitivity to body mass fluctuations, as reduction with controlled intentional weight regain showed an inverse relationship to VAT and occurred despite stable HMWAdp and sustained improvements with insulin resistance. FAI showed opposite changes to SHBG, while T did not change significantly with weight. Continued exercise during weight regain did not appear to impact these findings.
刻意减重及体重反弹对女性血清雄激素有何影响？我们对一项随机对照试验中前瞻性收集的样本进行了辅助分析。该试验包括在4 - 6个月内通过饮食和运动进行有监督的10%体重减轻（平均减重8.5千克），随后在4 - 6个月内进行有监督的刻意体重反弹，反弹至减重重量的50%（平均反弹4.6千克）。在部分体重反弹阶段之前，参与者被随机分为继续或停止耐力运动两组。分析样本包括30名患有代谢综合征的肥胖绝经前女性（平均年龄40±5.9岁，平均基线体重指数（BMI）为32.9±4.2千克/平方米）。我们评估了性激素结合球蛋白（SHBG）、总睾酮（T）、游离雄激素指数（FAI）和高分子量脂联素（HMWAdp）。对原始试验中测量的胰岛素、稳态模型评估（HOMA）、定量胰岛素敏感性检查指数（QUICKI）以及内脏脂肪组织（VAT），针对当前分析样本重新进行了分析。胰岛素、HOMA和QUICKI随体重减轻而改善，且体重反弹后仍保持改善状态。经对数转换的SHBG从基线到体重减轻阶段显著增加，然后随体重反弹显著下降。LogFAI和LogVAT变化类似，随体重减轻而下降，随体重反弹而增加。LogT和LogHMWAdp未发现变化。两组之间在任何测试参数上，运动与否均无显著差异。SHBG对体重波动表现出显著敏感性，因为在刻意控制体重反弹过程中其降低与VAT呈负相关，且尽管HMWAdp稳定且胰岛素抵抗持续改善，但仍出现这种情况。FAI与SHBG变化相反，而T随体重变化不显著。体重反弹期间继续运动似乎并未影响这些结果。
