Davis S, Potgieter P D, Linton D M
Respiratory Intensive Care Unit, Groote Schuur Hospital, South Africa.
Anaesth Intensive Care. 1989 May;17(2):170-4. doi: 10.1177/0310057X8901700208.
This study evaluates mandatory minute volume (MMV) weaning in patients with pulmonary pathology. When weaning criteria were fulfilled, 22 patients were randomised to MMV and 18 to a control intermittent mandatory ventilation (IMV) group. With IMV weaning the ventilator rate was decreased by two breaths per minute at 3-4 hourly intervals during daylight hours. In the MMV group a target of 75% of the ventilator minute volume was set. All weans were considered complete four hours after the cessation of mechanical support, and were deemed successful if no further ventilation was required. The success rate was 86% in the IMV and 89% in the MMV group. MMV weaning was rapid (4.75 + 1.5 hrs) and proved less demanding on the ICU staff by providing a safe trial of spontaneous respiration, while retaining the facility for partial ventilation.
本研究评估了肺部疾病患者的强制分钟通气量（MMV）撤机情况。当达到撤机标准时，22例患者被随机分配至MMV组，18例患者被分配至对照间歇强制通气（IMV）组。采用IMV撤机时，在白天每隔3 - 4小时将呼吸机频率每分钟降低2次呼吸。在MMV组中，设定了呼吸机分钟通气量75%的目标。所有撤机在机械支持停止4小时后被视为完成，若无需进一步通气则视为成功。IMV组的成功率为86%，MMV组为89%。MMV撤机速度快（4.75 + 1.5小时），通过提供安全的自主呼吸试验，同时保留部分通气功能，对ICU工作人员的要求较低。
