Hopkins Ramona O, Suchyta Mary R, Beene Katrin, Jackson James C
Department of Psychology and Neuroscience Center, Brigham Young University.
Department of Medicine, Pulmonary and Critical Care Medicine, Intermountain Medical Center, University of Utah.
Rehabil Psychol. 2016 May;61(2):151-64. doi: 10.1037/rep0000088.
The increasing likelihood of surviving critical illness has resulted in a large and growing number of individuals transitioning from medical and surgical intensive care units (ICUs) to their homes. Many ICU survivors develop pervasive morbidities in physical, psychological, and cognitive functioning that adversely impact day-to-day functioning, ability to return to work, and quality-of-life. These individuals have been extensively studied with neuropsychological test batteries, but relatively little research has been conducted using neuroimaging. This paper reviews neuroimaging findings in survivors of critical illness treated in medical or surgical ICUs.
We assessed the relationships between abnormalities on neuroimaging and cognitive outcomes and discussed the implications for rehabilitation.
There are limited imaging studies in ICU survivors. These studies use a wide range of modalities including magnetic resonance imaging (MRI), functional magnetic resonance imaging (fMRI), diffusion tensor imaging (DTI), fluid attenuated inversion recovery (FLAIR), and diffusion weighted imaging. Structural abnormalities in survivors of critical illness include cortical and subcortical lesions, white matter hyperintensities (WMHs), and generalized and focal atrophy. These abnormalities persist months to years after ICU discharge and are associated with cognitive impairments. (PsycINFO Database Record
危重病存活可能性的增加导致大量且数量不断增长的个体从内科和外科重症监护病房（ICU）过渡到家中。许多ICU幸存者在身体、心理和认知功能方面出现普遍的疾病，对日常功能、重返工作岗位的能力和生活质量产生不利影响。这些个体已经通过神经心理测试组合进行了广泛研究，但使用神经影像学进行的研究相对较少。本文综述了在内科或外科ICU接受治疗的危重病幸存者的神经影像学研究结果。
我们评估了神经影像学异常与认知结果之间的关系，并讨论了其对康复的影响。
ICU幸存者的影像学研究有限。这些研究使用了多种模式，包括磁共振成像（MRI）、功能磁共振成像（fMRI）、扩散张量成像（DTI）、液体衰减反转恢复序列（FLAIR）和扩散加权成像。危重病幸存者的结构异常包括皮质和皮质下病变、白质高信号（WMH）以及广泛性和局灶性萎缩。这些异常在ICU出院后持续数月至数年，并与认知障碍相关。（PsycINFO数据库记录）
