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来自沙漠蝗（Schistocerca gregaria）的一种类FMRF酰胺神经肽——血吸虫F酰胺的分离、一级结构及生物活性

Isolation, primary structure and bioactivity of schistoflrf-amide, a FMRF-amide-like neuropeptide from the locust, Schistocerca gregaria.

作者信息

Robb S, Packman L C, Evans P D

机构信息

AFRC Unit of Insect Neurophysiology and Pharmacology, Dept. of Zoology, University of Cambridge, UK.

出版信息

Biochem Biophys Res Commun. 1989 Apr 28;160(2):850-6. doi: 10.1016/0006-291x(89)92512-6.

DOI:10.1016/0006-291x(89)92512-6
PMID:2719702
Abstract

We have isolated a neuropeptide, related to the Phe-Met-Arg-Phe-NH2 family, from the thoracic nervous system of the locust, Schistocerca gregaria, using a purification system based on the radioimmunoassay of high pressure liquid chromatography fractions. The primary sequence of this locust peptide is Pro-Asp-Val-Asp-His-Val-Phe-Leu-Arg-Phe-NH2. The bioactivities of the native and synthetic neuropeptide are identical in both the locust heart and hindleg extensor-tibiae muscle bioassays.

摘要

我们利用基于高压液相色谱馏分放射免疫分析的纯化系统，从沙漠蝗（Schistocerca gregaria）的胸神经系统中分离出一种与苯丙氨酸 - 蛋氨酸 - 精氨酸 - 苯丙氨酸 - 酰胺（Phe - Met - Arg - Phe - NH2）家族相关的神经肽。这种蝗虫肽的一级序列是脯氨酸 - 天冬氨酸 - 缬氨酸 - 天冬氨酸 - 组氨酸 - 缬氨酸 - 苯丙氨酸 - 亮氨酸 - 精氨酸 - 苯丙氨酸 - 酰胺（Pro - Asp - Val - Asp - His - Val - Phe - Leu - Arg - Phe - NH2）。在蝗虫心脏和后肢伸胫肌生物测定中，天然神经肽和合成神经肽的生物活性相同。

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