Department of Radiology, Seoul National University Bundang Hospital, Seongnam, Korea.
Department of Radiology, Seoul National University College of Medicine, Seoul, Korea.
Ultrasonography. 2016 Oct;35(4):309-17. doi: 10.14366/usg.16006. Epub 2016 Apr 14.
The use of gas-filled microbubbles in perfusion monitoring as intravascular ultrasound contrast agents has recently become more common. Additionally, microbubbles are employed as carriers of pharmaceutical substances or genes. Microbubbles have great potential to improve the delivery of therapeutic materials into cells and to modify vascular permeability, causing increased extravasation of drugs and drug carriers. Prostate cancer is the most common neoplasm in Europe and America, with an incidence twice to three times that of lung and colorectal cancer. Its incidence is still rising in Asian countries, including Japan and Korea. In this review, we present current strategies regarding the synthesis of microbubbles with targeted ligands on their surfaces, with a focus on prostate cancer.
在灌注监测中使用充气体微泡作为血管内超声对比剂最近变得越来越普遍。此外，微泡还被用作药物物质或基因的载体。微泡具有将治疗材料递送到细胞内并改变血管通透性的巨大潜力，导致药物和药物载体的外渗增加。前列腺癌是欧美最常见的肿瘤，其发病率是肺癌和结直肠癌的两倍至三倍。包括日本和韩国在内的亚洲国家的发病率仍在上升。在这篇综述中，我们介绍了目前关于在表面带有靶向配体的微泡合成的策略，重点是前列腺癌。
