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IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance.

作者信息

Imamura T, Yano M, Asai D, Moriya-Saito A, Suenobu S-I, Hasegawa D, Deguchi T, Hashii Y, Kawasaki H, Hori H, Yumura-Yagi K, Hara J, Horibe K, Sato A

机构信息

Department of Pediatrics, Kyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.

Japan Association of Childhood Leukemia Study Group (JACLS), Suita, Japan.

出版信息

Leukemia. 2016 Aug;30(8):1801-3. doi: 10.1038/leu.2016.128. Epub 2016 May 20.

DOI:10.1038/leu.2016.128
PMID:27198053
Abstract
摘要

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IKZF1 deletion is enriched in pediatric B-cell precursor acute lymphoblastic leukemia patients showing prednisolone resistance.IKZF1缺失在表现出泼尼松耐药的儿童B细胞前体急性淋巴细胞白血病患者中更为常见。
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本文引用的文献

1
Tumor suppressor IKZF1 mediates glucocorticoid resistance in B-cell precursor acute lymphoblastic leukemia.肿瘤抑制因子IKZF1介导B细胞前体急性淋巴细胞白血病中的糖皮质激素抵抗。
Leukemia. 2016 Jul;30(7):1599-603. doi: 10.1038/leu.2015.359. Epub 2015 Dec 29.
2
Protracted Administration of L-Asparaginase in Maintenance Phase Is the Risk Factor for Hyperglycemia in Older Patients with Pediatric Acute Lymphoblastic Leukemia.在维持期长期使用左旋门冬酰胺酶是老年儿童急性淋巴细胞白血病患者发生高血糖的危险因素。
PLoS One. 2015 Aug 28;10(8):e0136428. doi: 10.1371/journal.pone.0136428. eCollection 2015.
3
Loss of TBL1XR1 disrupts glucocorticoid receptor recruitment to chromatin and results in glucocorticoid resistance in a B-lymphoblastic leukemia model.
克服小儿急性淋巴细胞白血病的类固醇耐药性——最新知识和未来展望。
Int J Mol Sci. 2022 Mar 30;23(7):3795. doi: 10.3390/ijms23073795.
4
CRLF2 and IKZF1 abnormalities in Mexican children with acute lymphoblastic leukemia and recurrent gene fusions: exploring surrogate markers of signaling pathways.患有急性淋巴细胞白血病和复发性基因融合的墨西哥儿童中的CRLF2和IKZF1异常：探索信号通路的替代标志物
J Pathol Clin Res. 2021 Jul;7(4):410-421. doi: 10.1002/cjp2.211. Epub 2021 Apr 23.
5
Multiclonal complexity of pediatric acute lymphoblastic leukemia and the prognostic relevance of subclonal mutations.儿童急性淋巴细胞白血病的多克隆复杂性和亚克隆突变的预后相关性。
Haematologica. 2021 Dec 1;106(12):3046-3055. doi: 10.3324/haematol.2020.259226.
6
Copy number alterations in B-cell development genes, drug resistance, and clinical outcome in pediatric B-cell precursor acute lymphoblastic leukemia.儿童 B 细胞前体急性淋巴细胞白血病中 B 细胞发育基因的拷贝数改变、耐药性和临床结局。
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7
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Haematologica. 2018 Apr;103(4):565-574. doi: 10.3324/haematol.2017.185603. Epub 2018 Mar 8.
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Nature. 2011 Mar 10;471(7337):235-9. doi: 10.1038/nature09727.
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ETV6/RUNX1-positive relapses evolve from an ancestral clone and frequently acquire deletions of genes implicated in glucocorticoid signaling.ETV6/RUNX1 阳性复发源自于一个祖细胞克隆，并且经常获得涉及糖皮质激素信号的基因缺失。
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Integrated use of minimal residual disease classification and IKZF1 alteration status accurately predicts 79% of relapses in pediatric acute lymphoblastic leukemia.微小残留病灶分类与 IKZF1 改变状态的综合应用可准确预测儿童急性淋巴细胞白血病 79%的复发。
Leukemia. 2011 Feb;25(2):254-8. doi: 10.1038/leu.2010.275. Epub 2010 Nov 19.