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The need for reassessment of digoxin prescribing for the elderly.

作者信息

Nolan L, Kenny R, O'Malley K

机构信息

Department of Clinical Pharmacology, Royal College of Surgeons in Ireland, St Stephen's Green, Dublin.

出版信息

Br J Clin Pharmacol. 1989 Mar;27(3):367-70. doi: 10.1111/j.1365-2125.1989.tb05378.x.

Abstract
  1. The prevalence and circumstance of digoxin prescribing was assessed in five private nursing homes. 2. Forty-one patients (21% residents) were taking digoxin. 3. Seventeen patients were in atrial fibrillation and the remainder in sinus rhythm. The ventricular rate exceeded 100 beats min-1 in eight of the 17 patients in atrial fibrillation. 4. Thirty-seven patients were prescribed 0.0625 mg digoxin daily and serum digoxin concentrations were subtherapeutic in 20 of 32 patients in whom concentrations were measured. 5. These data indicate a need for more careful review of the need for maintenance digoxin and illustrate the inappropriateness of routinely prescribing very low doses in all elderly patients.
摘要

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The need for reassessment of digoxin prescribing for the elderly.
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本文引用的文献

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Heart failure in outpatients: a randomized trial of digoxin versus placebo.
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