Schuttelaar Marie-Louise A, Vogel Tatiana A, Rui Francesca, Kręcisz Beata, Chomiczewska-Skora Dorota, Kieć-Świerczyńska Marta, Uter Wolfgang, Larese Filon Francesca
Dermatology, University Medical Center Groningen, University of Groningen, 9700 RB, Groningen, The Netherlands.
Department of Medical Sciences, Clinical Unit of Occupational Medicine, University of Trieste, 34129, Trieste, Italy.
Contact Dermatitis. 2016 Sep;75(3):165-72. doi: 10.1111/cod.12583. Epub 2016 May 19.
Allergic contact dermatitis caused by p-phenylenediamine (PPD) is common among all age groups and both sexes. Monitoring of prevalence and intensity of sensitization is important.
To evaluate contact allergy to PPD in Europe, and to compare reaction intensities in different European regions.
Data collected by the European Surveillance System on Contact Allergies (ESSCA) network between 2002 and 2012 from 12 European countries were analysed regarding prevalence, grading of positive reactions to PPD, and relevance.
A total of 99 926 PPD-positive patients from 63 departments were included for analysis. The overall (2002-2012) prevalence of PPD sensitization in Europe is ∼4%. Stratified for country, the highest overall standardized prevalence was found in Lithuania, and the lowest in Slovenia. The prevalence of PPD sensitization did not decline over the years. In the southern European countries, higher numbers of strong and extremely strong reactions were registered. The clinical relevance of PPD sensitization varied from half to three-quarters.
The prevalence of PPD sensitization has not changed over time. Strong and extremely strong patch test reactions are seen more often in the South, probably because of the higher number of PPD-containing hair dye products.
对苯二胺（PPD）引起的过敏性接触性皮炎在所有年龄组和男女中都很常见。监测致敏的患病率和强度很重要。
评估欧洲对PPD的接触性过敏，并比较欧洲不同地区的反应强度。
分析了欧洲接触性过敏监测系统（ESSCA）网络在2002年至2012年期间从12个欧洲国家收集的数据，内容涉及患病率、对PPD阳性反应的分级以及相关性。
共纳入了来自63个科室的99926例PPD阳性患者进行分析。欧洲PPD致敏的总体（2002 - 2012年）患病率约为4%。按国家分层，立陶宛的总体标准化患病率最高，斯洛文尼亚最低。PPD致敏的患病率多年来并未下降。在南欧国家，记录到的强反应和极强反应数量更多。PPD致敏的临床相关性从一半到四分之三不等。
PPD致敏的患病率随时间未发生变化。在南方，强和极强的斑贴试验反应更常见，可能是因为含PPD的染发剂产品数量较多。
