Loman Laura, Uter Wolfgang, Armario-Hita José C, Ayala Fabio, Balato Anna, Ballmer-Weber Barbara K, Bauer Andrea, Bircher Andreas J, Buhl Timo, Czarnecka-Operacz Magdalena, Dickel Heinrich, Fuchs Thomas, Giménez Arnau Ana, John Swen M, Kränke Birger, Kręcisz Beata, Mahler Vera, Rustemeyer Thomas, Sadowska-Przytocka Anna, Sánchez-Pérez Javier, Scherer Hofmeier Kathrin, Schliemann Sibylle, Simon Dagmar, Spiewak Radoslaw, Spring Philip, Valiukevičienė Skaidra, Wagner Nicola, Weisshaar Elke, Pesonen Maria, Schuttelaar Marie L A
Department of Dermatology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
Department of Medical Informatics, Biometry and Epidemiology, Friedrich-Alexander-University Erlangen/Nürnberg, Erlangen, Germany.
Contact Dermatitis. 2021 Mar 17;85(2):186-97. doi: 10.1111/cod.13833.
Irritant contact dermatitis (ICD) is caused by the acute locally toxic effect of a strong irritant, or the cumulative exposure to various weaker physical and/or chemical irritants.
To describe the characteristics of patients with ICD in the population patch tested in the European Surveillance System on Contact Allergies (ESSCA; www.essca-dc.org) database.
Data collected by the ESSCA in consecutively patch-tested patients from January 2009 to December 2018 were analyzed.
Of the 68 072 patients, 8702 were diagnosed with ICD (without concomitant allergic contact dermatitis [ACD]). Hand and face were the most reported anatomical sites, and 45.7% of the ICD was occupational ICD (OICD). The highest proportions of OICD were found in metal turners, bakers, pastry cooks, and confectionery makers. Among patients diagnosed with ICD, 45% were found sensitized with no relevance for the current disease.
The hands were mainly involved in OICD also in the subgroup of patients with contact dermatitis, in whom relevant contact sensitization had been ruled out, emphasizing the need for limiting irritant exposures. However, in difficult-to-treat contact dermatitis, unrecognized contact allergy, or unrecognized clinical relevance of identified allergies owing to incomplete or wrong product ingredient information must always be considered.
刺激性接触性皮炎（ICD）是由强刺激物的急性局部毒性作用，或对各种较弱的物理和/或化学刺激物的累积接触引起的。
描述在欧洲接触性过敏监测系统（ESSCA；www.essca-dc.org）数据库中进行斑贴试验的人群中ICD患者的特征。
对ESSCA在2009年1月至2018年12月连续进行斑贴试验的患者收集的数据进行分析。
在68072例患者中，8702例被诊断为ICD（无合并过敏性接触性皮炎[ACD]）。手部和面部是报告最多的解剖部位，45.7%的ICD为职业性ICD（OICD）。OICD比例最高的是金属车工、面包师、糕点厨师和糖果制造商。在诊断为ICD的患者中，45%被发现致敏，但与当前疾病无关。
在排除了相关接触致敏的接触性皮炎患者亚组中，手部也是OICD的主要受累部位，这强调了限制刺激性暴露的必要性。然而，在难治性接触性皮炎中，必须始终考虑未被识别的接触性过敏，或由于产品成分信息不完整或错误而导致的已识别过敏的未被识别的临床相关性。
