Lee Jung Min, Kyeong Sunghyun, Kim Eunjoo, Cheon Keun-Ah
Division of Computational Mathematics, National Institute for Mathematical Sciences Daejeon, South Korea.
Severance Biomedical Science Institute, Yonsei University College of Medicine Seoul, South Korea.
Front Neurosci. 2016 May 3;10:191. doi: 10.3389/fnins.2016.00191. eCollection 2016.
Recently, the Autism Brain Imaging Data Exchange (ABIDE) project revealed decreased functional connectivity in individuals with Autism Spectrum Disorders (ASD) relative to the typically developing controls (TDCs). However, it is still questionable whether the source of functional under-connectivity in subjects with ASD is equally contributed by the ipsilateral and contralateral parts of the brain. In this study, we decomposed the inter- and intra-hemispheric regions and compared the functional connectivity density (FCD) between 458 subjects with ASD and 517 TDCs from the ABIDE database. We quantified the inter- and intra-hemispheric FCDs in the brain by counting the number of functional connectivity with all voxels in the opposite and same hemispheric brain regions, respectively. Relative to TDCs, both inter- and intra-hemispheric FCDs in the posterior cingulate cortex, lingual/parahippocampal gyrus, and postcentral gyrus were significantly decreased in subjects with ASD. Moreover, in the ASD group, the restricted and repetitive behavior subscore of the Autism Diagnostic Observation Schedule (ADOS-RRB) score showed significant negative correlations with the average inter-hemispheric FCD and contralateral FCD in the lingual/parahippocampal gyrus cluster. Also, the ADOS-RRB score showed significant negative correlations with the average contralateral FCD in the default mode network regions such as the posterior cingulate cortex and precuneus. Taken together, our findings imply that a deficit of non-social functioning processing in ASD such as restricted and repetitive behaviors and sensory hypersensitivity could be determined via both inter- and intra-hemispheric functional disconnections.
最近，自闭症脑成像数据交换（ABIDE）项目显示，与正常发育的对照组（TDC）相比，自闭症谱系障碍（ASD）患者的功能连接性降低。然而，ASD患者功能连接不足的根源是否由大脑的同侧和对侧部分同等造成，仍存在疑问。在本研究中，我们分解了半球间和半球内区域，并比较了来自ABIDE数据库的458名ASD患者和517名TDC患者之间的功能连接密度（FCD）。我们通过分别计算与对侧和同侧脑区所有体素的功能连接数量，对大脑中的半球间和半球内FCD进行了量化。与TDC相比，ASD患者后扣带回皮质、舌回/海马旁回和中央后回的半球间和半球内FCD均显著降低。此外，在ASD组中，自闭症诊断观察量表（ADOS-RRB）评分中的受限和重复行为子分数与舌回/海马旁回簇中的平均半球间FCD和对侧FCD呈显著负相关。而且，ADOS-RRB评分与默认模式网络区域（如后扣带回皮质和楔前叶）中的平均对侧FCD也呈显著负相关。综上所述，我们的研究结果表明，ASD患者在非社交功能处理方面的缺陷，如受限和重复行为以及感觉过敏，可能通过半球间和半球内的功能断开连接来确定。
