Levitt A J, Joffe R T
Department of Psychiatry, University of Toronto, Ontario, Canada.
Biol Psychiatry. 1989 Apr 1;25(7):867-72. doi: 10.1016/0006-3223(89)90266-7.
Forty-four consecutive, unmedicated outpatients with a major depressive disorder were evaluated to determine the relationships in life course, severity of depressive illness, and serum folate and B12 levels. Duration of current episode was significantly inversely correlated with folate levels. Age at onset of illness was significantly correlated with B12. In a subgroup of recurrent depressives, current age and age at onset of depressive illness were positively correlated with folate. The findings are discussed in light of the current hypotheses regarding the association of folate and mood.
对44名患有重度抑郁症的连续未用药门诊患者进行评估，以确定生命历程、抑郁疾病严重程度与血清叶酸和维生素B12水平之间的关系。当前发作的持续时间与叶酸水平显著负相关。发病年龄与维生素B12显著相关。在复发性抑郁症患者亚组中，当前年龄和抑郁疾病发病年龄与叶酸呈正相关。根据目前关于叶酸与情绪关联的假说对这些发现进行了讨论。
