[抑郁症住院患者的血清叶酸和维生素B12。一项对121例抑郁症住院患者采用放射免疫分析法检测血清叶酸的研究]

[Serum folic acid and vitamin B12 in depressed inpatients. A study of serum folic acid with radioimmunoassay in 121 depressed inpatients].

作者信息

Wolfersdorf M, König F

机构信息

Abteilung Psychiatrie I der Universität Ulm, PLK Weissenau, Ravensburg-Weissenau.

出版信息

Psychiatr Prax. 1995 Jul;22(4):162-4.

PMID:7675908

Abstract

According to the newer literature on folate deficiencies in depressive patients serum folate and vitamin B12 levels were studied (RIA) in 121 consecutively admitted depressive inpatients (47 male, 74 female depressives; age 17-86 years, mean age 48 years, diagnostic by ICD-9 300.4, 296.1) during the first (1-3) days of admission (normal volumes folate 3-17 ng/ml, vitamin B12 200-900 pg/ml). Only in two patients serum folate below 3 ng/ml were found, low vitamin B12 levels (below 200 pg/ml) showed 14 patients. This result is in contrast to other authors who found folate deficiencies in 10-50% of psychiatric patients.

摘要

根据关于抑郁症患者叶酸缺乏的最新文献，对121例连续入院的抑郁住院患者（47例男性、74例女性抑郁症患者；年龄17 - 86岁，平均年龄48岁，根据ICD - 9诊断为300.4、296.1）在入院的头（1 - 3）天进行了血清叶酸和维生素B12水平研究（放射免疫分析）（正常叶酸水平为3 - 17 ng/ml，维生素B12为200 - 900 pg/ml）。仅在2例患者中发现血清叶酸低于3 ng/ml，14例患者维生素B12水平较低（低于200 pg/ml）。这一结果与其他作者的研究结果相反，其他作者发现10% - 50%的精神科患者存在叶酸缺乏。