University of Illinois College of Medicine , Peoria, IL , USA.
University of Illinois College of Medicine, Peoria, IL, USA; Associate Medical Director, Research and Development, Abbvie, Chicago, IL, USA.
Front Pediatr. 2016 May 6;4:45. doi: 10.3389/fped.2016.00045. eCollection 2016.
C3 glomerulopathy is an umbrella term, which includes several rare forms of glomerulonephritis (GN) with underlying defects in the alternate complement cascade. A common histological feature noted in all these GN is dominant C3 deposition in the glomerulus. In this review, we will provide an overview of the complement system as well as mediators, with an introduction to pharmaceutical agents that can alter the pathway.
C3 肾小球病是一个总称，包括几种罕见的肾小球肾炎 (GN)，其根本缺陷在于替代补体级联。所有这些 GN 的一个共同组织学特征是肾小球中占主导地位的 C3 沉积。在这篇综述中，我们将提供补体系统以及介质的概述，并介绍可以改变途径的药物制剂。
