Centre for Complement and Inflammation Research, Imperial College London, London, UK.
Kidney Int. 2013 Dec;84(6):1079-89. doi: 10.1038/ki.2013.377. Epub 2013 Oct 30.
C3 glomerulopathy is a recently introduced pathological entity whose original definition was glomerular pathology characterized by C3 accumulation with absent or scanty immunoglobulin deposition. In August 2012, an invited group of experts (comprising the authors of this document) in renal pathology, nephrology, complement biology, and complement therapeutics met to discuss C3 glomerulopathy in the first C3 Glomerulopathy Meeting. The objectives were to reach a consensus on: the definition of C3 glomerulopathy, appropriate complement investigations that should be performed in these patients, and how complement therapeutics should be explored in the condition. This meeting report represents the current consensus view of the group.
C3 肾小球病是一种新引入的病理实体,其最初的定义是肾小球病理学特征为 C3 积聚,而免疫球蛋白沉积缺失或稀少。2012 年 8 月,一组肾脏病理学、肾脏病学、补体生物学和补体治疗学的特邀专家(包括本文作者)在第一次 C3 肾小球病会议上讨论了 C3 肾小球病。目的是就以下方面达成共识:C3 肾小球病的定义、应在这些患者中进行的适当补体检查以及如何在该疾病中探索补体治疗。本会议报告代表了该小组目前的共识意见。