Bekiarova G I, Markova M P, Kagan V G
Biull Eksp Biol Med. 1989 Apr;107(4):413-5.
It is shown that skin burn is accompanied by activation of lipid peroxidation (accumulation of TBA-reactive substances and of fluorescent end-products) in the blood of experimental animals. The decrease in red blood cell membrane stability was demonstrated exerting as increase in the rate of spontaneous hemolysis, content of extraerythrocyte++ haemoglobin and increased sensitivity to exogenous oleic acid. It is estimated that alpha-tocopherol possesses protective stabilizing effect on red blood cell membrane. This stabilizing action is observed when alpha-tocopherol was injected both before the skin burn and immediately after it. It is concluded that two different mechanisms are responsible for stabilizing effect of tocopherol, namely: 1) antiradical, realized via inhibition of lipid peroxidation, and 2) non-antioxidant, caused by interaction of tocopherol with phospholipid hydrolysis products by phospholipases A2 (free fatty acids and lysophospholipids).
结果表明，实验动物血液中皮肤烧伤伴随着脂质过氧化的激活（TBA反应性物质和荧光终产物的积累）。红细胞膜稳定性的降低表现为自发溶血速率增加、红细胞外血红蛋白含量增加以及对外源性油酸的敏感性增加。据估计，α-生育酚对红细胞膜具有保护稳定作用。当在皮肤烧伤前和烧伤后立即注射α-生育酚时，均可观察到这种稳定作用。得出的结论是，生育酚的稳定作用由两种不同机制引起，即：1）抗自由基作用，通过抑制脂质过氧化实现；2）非抗氧化作用，由生育酚与磷脂酶A2的磷脂水解产物（游离脂肪酸和溶血磷脂）相互作用引起。
