Rusakov V I, Lukash N A, Prokof'eva M S
Biull Eksp Biol Med. 1989 Apr;107(4):435-7.
The amino acid composition of red blood cell membrane proteins had been studied in different stages of acute intestinal obstruction. Hydrophobic amino acids were revealed to increase and glutamate was found to decrease during the early period of acute intestinal obstruction. Later neutral amino acids and some of the main amino acids were stated to decrease. Shifts in the ratio of protein fractions seen in red blood cell membrane of rats with acute intestinal obstruction could be explained by changes followed in the amino acid composition. The data accumulated had demonstrated that such a significant modification of protein component of the red blood cell membrane could be one of the reasons of the erythrocyte membrane penetrability violation and could play the pathogenetic role in the occurrence of irreversibility changes in cases of the intestinal obstruction. All that was mentioned above had shown the necessity to use membrane protectors and antienzyme drugs in the postoperative period.
在急性肠梗阻的不同阶段对红细胞膜蛋白的氨基酸组成进行了研究。结果显示，在急性肠梗阻早期，疏水性氨基酸增加，谷氨酸减少。之后中性氨基酸和一些主要氨基酸减少。急性肠梗阻大鼠红细胞膜中蛋白质组分比例的变化可以用氨基酸组成的改变来解释。积累的数据表明，红细胞膜蛋白质成分的这种显著改变可能是红细胞膜通透性受损的原因之一，并且在肠梗阻病例中不可逆变化的发生中可能起致病作用。上述所有情况表明在术后阶段有必要使用膜保护剂和抗酶药物。
